Publications by authors named "Andrea Gagliardi"
NPM1 is the most frequently mutated gene in adults with acute myeloid leukemia (AML). The interaction between mutant NPM1 (NPM1c) and exportin-1 (XPO1) causes aberrant cytoplasmic dislocation of NPM1c and promotes the high expression of homeobox (HOX) genes, which is critical for maintaining the leukemic state of NPM1-mutated cells. Although there is a rationale for using XPO1 inhibitors in NPM1-mutated AML, selinexor administered once or twice per week did not translate into clinical benefit in patients with NPM1 mutations.
View Article and Find Full Text PDFFresh olive mill wastewaters phenolic extracts are of great interest as preservatives or fortifying ingredients but are characterized by limited stability. The purpose of this study was to use mesoporous silica to enhance their stability and preserve their antioxidant properties. The phenolic extracts were characterized for their composition by HPLC-DAD and included in a mesoporous matrix with or without a lipid coating.
View Article and Find Full Text PDFLiver fibrosis (LF) is a dangerous clinical condition with no available treatment. Inflammation plays a critical role in LF progression. Glucocorticoid-induced leucine zipper (GILZ, encoded in mice by the Tsc22d3 gene) mimics many of the anti-inflammatory effects of glucocorticoids, but its role in LF has not been directly addressed.
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- Targeting myocardial remodeling and the signaling involved is crucial for improving heart failure prognosis, as current strategies are ineffective against hypertrophy, a significant predictor of heart failure progression and mortality.
- A study using GILZ-knockout (KO) mice demonstrated that absence of GILZ worsened diastolic dysfunction and enhanced hypertrophic response following Angiotensin II (Ang II) infusion compared to wild-type (WT) mice.
- While inflammation and fibrosis responses to Ang II were similar in both types of mice, GILZ-KO mice showed a lack of regulatory response from GATA4 and FoxP3, indicating GILZ plays an important role in cardiovascular pathology.
Glucocorticoid-induced leucine zipper (GILZ) is transcriptionally upregulated by glucocorticoids (GCs) and mediates many of the anti-inflammatory effects of GCs. Since B cell activity has been linked to cytokine production and modulation of inflammatory responses, we herein investigated the role of GILZ in B cells during colitis development. B cell-specific knock-out (gilz B cKO) mice exhibited increased production of the pro-inflammatory cytokine IFN-γ in B cells, and consequently CD4 T cell activation.
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