Publications by authors named "Andrea Fuentes-Moliz"
Article Synopsis
- Researchers discovered a variant of the Hspa8 chaperone in model mice that significantly improved lifespan, motor function, and neuromuscular health in SMA-affected mice.
- The study revealed that Hspa8 influences SMN2 splicing and promotes a crucial chaperone complex formation for synaptic stability, shedding light on the mechanisms behind motor neuron degeneration in SMA.
Presynaptic Ca regulation is critical for accurate neurotransmitter release, vesicle reloading of release sites, and plastic changes in response to electrical activity. One of the main players in the regulation of cytosolic Ca in nerve terminals is mitochondria, which control the size and spread of the Ca wave during sustained electrical activity. However, the role of mitochondria in Ca signaling during high-frequency short bursts of action potentials (APs) is not well known.
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