[Personalized medicine and healthcare: where are we now, where should we go?].

The authors of this manuscript are representatives of different subdisciplines of medicine, all of them are experienced researchers. As of their origin, they are practicing doctors from the primary care and from the clinical/hospital setting, diagnostics experts, researchers from healthcare management, health economics, representatives of patients' rights and patient organizations. They are all devoted to the implementation of personalized medicine and personalized healthcare in Hungary.

Intraarticular Injection of a Cross-Linked Sodium Hyaluronate Combined with Triamcinolone Hexacetonide (Cingal) to Provide Symptomatic Relief of Osteoarthritis of the Knee: A Randomized, Double-Blind, Placebo-Controlled Multicenter Clinical Trial.

Objective: To evaluate the efficacy and safety of an intraarticular injection of Cingal (Anika Therapeutics, Inc., Bedford, MA) compared with Monovisc (Anika Therapeutics, Inc., Bedford, MA) or saline for the treatment of knee osteoarthritis.

Balneotherapy in elderly patients: effect on pain from degenerative knee and spine conditions and on quality of life.

Background: Balneotherapy is an established treatment modality for musculoskeletal disease, but few studies have examined the efficacy of spa therapy in elderly patients with degenerative spine and joint diseases.

Objectives: To assess the effects of balneotherapy on chronic musculoskeletal pain, functional capacity, and quality of life in elderly patients with osteoarthritis of the knee or with chronic low back pain.

Methods: The 81 patients in the study group underwent a 1 day course of 30 minute daily baths in mineral water.

[Assessment of cerebrovascular reactivity using the breath-holding test in hypertensive and normotensive adolescents--preliminary results].

Aim: Authors report on preliminary results of cerebral vasoreactivity-tests performed in frame of the Debrecen Hypertension Study among hypertensive and healthy adolescents.

Methods: Investigators measured blood flow velocities before and after 30 seconds of breath holding using transcranial Doppler sonography.

Results: Blood flow velocities at rest were significantly higher in the hypertensive that in the healthy adolescent group.

Comparison of different methods evaluating the functional and structural abnormalities in hypertension.

Functional and morphological abnormalities due to hypertension could be detected in neurologically symptom-free patients by CT, MRI, transcranial Doppler ultrasound, PET and SPECT. Neuropsychological tests also provide useful information. Single or combined application of these techniques reveals different aspects of parenchymal or vascular impairment in hypertension.

[Treatment of migraine in patients with hypertension and ischemic heart disease].

Migraine is a common disorder with a prevalence of 9-10% in Hungary. Migraine can be accompanied by hypertension and/or ischemic heart disease sometimes in younger patients, but more frequently in the elderly, which is important for therapeutical considerations. The article reviews the literature with special focus on hypertension and coronary heart disease.