Publications by authors named "Andrea Feu-Llaurado"
RCAN proteins are endogenous regulators of the calcineurin-cytosolic nuclear factor of activated T cells (CN-NFATc) pathway that bind CN through similar conserved motifs PxIxIT and LxVP of the NFATc family. RCAN1 and RCAN3 protein levels were reported to correlate with overall survival of breast cancer patients. We additionally provided supporting results about RCAN3 role on cancer showing that overexpression of the native PxIxIT sequence of RCAN3-derived R3 peptide (PSVVVH, EGFP-R3178-210) dramatically inhibits tumor growth and tumor angiogenesis in an orthotopic mouse model of Triple Negative Breast Cancer (TNBC) in nude mice.
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- Predicting the clinical behavior of chromophobe renal cell carcinoma (ChRCC) has been difficult due to its diverse morphologic and genetic profiles.
- This study analyzed 89 rare subtypes of ChRCC compared to 70 classic/eosinophilic cases to see how histologic diversity affects survival outcomes.
- No significant differences in clinical outcomes were found between the rare subtypes and classic/eosinophilic groups, reinforcing that factors like sarcomatoid differentiation and tumor necrosis are linked to poorer outcomes across all subtypes.