Publications by authors named "Andrea Enriquez"
Article Synopsis
- NMNAT2, a critical enzyme for NAD synthesis, is essential for the health of axons in glutamatergic neurons, which are often affected in neurodegenerative diseases.
- Research showed that the loss of NMNAT2 leads to decreased ATP levels and impaired axonal transport, ultimately harming axonal integrity.
- The study found that supplementing NAD or inhibiting the enzyme SARM1 can help restore axonal function and protect against degeneration caused by NMNAT2 deficiency.
Background: Bioenergetic maladaptations and axonopathy are often found in the early stages of neurodegeneration. Nicotinamide adenine dinucleotide (NAD), an essential cofactor for energy metabolism, is mainly synthesized by Nicotinamide mononucleotide adenylyl transferase 2 (NMNAT2) in CNS neurons. NMNAT2 mRNA levels are reduced in the brains of Alzheimer's, Parkinson's, and Huntington's disease.
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- Peatlands play a crucial role in global carbon and nitrogen cycles, holding 15 to 30% of the world's soil carbon stock, but their varying chemistry complicates global carbon inventories.
- A study analyzed 436 peat cores from 24 countries, finding significant differences in carbon, nitrogen, and organic matter content between different peatland categories, mainly influenced by pH levels.
- The results indicate predictable differences in carbon and organic matter concentrations across peatland types, which can help enhance future assessments of global peatland carbon and nitrogen stocks.
Background: Health issues have been associated with the consumption of high levels of nitrates in drinking water. Rural agricultural communities in Belize play a large role in the economic growth of the country. These communities obtain drinking water directly from the ground and may be susceptible to nitrate consumption and at risk of developing diseases associated with nitrates.
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