Recurrent somatic mutations reveal new insights into consequences of mutagenic processes in cancer.

The sheer size of the human genome makes it improbable that identical somatic mutations at the exact same position are observed in multiple tumours solely by chance. The scarcity of cancer driver mutations also precludes positive selection as the sole explanation. Therefore, recurrent mutations may be highly informative of characteristics of mutational processes.

The size and composition of polymeric nanocapsules dictate their interaction with macrophages and biodistribution in zebrafish.

Macrophages are pivotal cells of the innate immune system specialized in the phagocytosis of foreign elements. Nanoparticles intentionally designed to target macrophages and modulate their response are of especial interest in the case of chronic inflammatory diseases, cancer and for vaccine development. This work aimed to understand the role of size and shell composition of polymeric nanocapsules (NCs) in their interaction with macrophages, both in vitro and in vivo.