Molecular Mechanism of Sirtuin 1 Modulation by the AROS Protein.

The protein lysine deacylases of the NAD-dependent Sirtuin family contribute to metabolic regulation, stress responses, and aging processes, and the human Sirtuin isoforms, Sirt1-7, are considered drug targets for aging-related diseases. The nuclear isoform Sirt1 deacetylates histones and transcription factors to regulate, e.g.