Development and Validation of Claims-Based Algorithms for Conjunctivitis and Keratitis.

Background: Ocular surface disorders have been reported among patients with various medical conditions, including atopic dermatitis (AD). Nonetheless, validated algorithms to identify conjunctivitis and keratitis in claims data are lacking.

Objective: Develop validated, claims-based algorithms for conjunctivitis and keratitis among patients with AD using medical records.

Development and Validation of ICD-10-CM-based Algorithms for Date of Last Menstrual Period, Pregnancy Outcomes, and Infant Outcomes.

Introduction And Objective: Validation studies of algorithms for pregnancy outcomes based on International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM) codes are important for conducting drug safety research using administrative claims databases. To facilitate the conduct of pregnancy safety studies, this exploratory study aimed to develop and validate ICD-10-CM-based claims algorithms for date of last menstrual period (LMP) and pregnancy outcomes using medical records.

Methods: Using a mother-infant-linked claims database, the study included women with a pregnancy between 2016-2017 and their infants.

Inpatient Constipation Among Migraine Patients Prescribed Anti-calcitonin Gene-Related Peptide Monoclonal Antibodies and Standard of Care Antiepileptic Drugs: A Retrospective Cohort Study in a United States Electronic Health Record Database.

Introduction: Erenumab, an anti-calcitonin gene-related peptide (CGRP) receptor monoclonal antibody (mAb), was approved by the US Food and Drug Administration in May 2018. Constipation with serious complications was added to the Warning and Precautions section in the erenumab Prescribing Information in October 2019 after events were observed during post-marketing surveillance. We aimed to assess and compare the risk of inpatient constipation, and, separately, inpatient constipation with serious complications, among patients with migraine treated with CGRP mAbs and standard of care antiepileptic drugs (AEDs).

Trends in COVID-19 patient characteristics in a large electronic health record database in the United States: A cohort study.

Background: Electronic health record (EHR) databases provide an opportunity to facilitate characterization and trends in patients with COVID-19.

Methods: Patients with COVID-19 were identified based on an ICD-10 diagnosis code for COVID-19 (U07.1) and/or a positive SARS-CoV-2 viral lab result from January 2020 to November 2020.

Predictors of critical care, mechanical ventilation, and mortality among hospitalized patients with COVID-19 in an electronic health record database.

Background: There are limited data on risk factors for serious outcomes and death from COVID-19 among patients representative of the U.S.

Population: The objective of this study was to determine risk factors for critical care, ventilation, and death among hospitalized patients with COVID-19.

Validity and Relative Validity of Alternative Methods of Assessing Physical Activity in Epidemiologic Studies: Findings From the Men's Lifestyle Validation Study.

In the Men's Lifestyle Validation Study (2011-2013), we examined the validity and relative validity of a physical activity questionnaire (PAQ), a Web-based 24-hour recall (Activities Completed Over Time in 24 Hours (ACT24)), and an accelerometer by multiple comparison methods. Over the course of 1 year, 609 men completed 2 PAQs, two 7-day accelerometer measurements, at least 1 doubly labeled water (DLW) physical activity level (PAL) measurement (n = 100 with repeat measurements), and 4 ACT24s; they also measured their resting pulse rate. A subset (n = 197) underwent dual-energy x-ray absorptiometry (n = 99 with repeated measurements).

Reproducibility, Validity, and Relative Validity of Self-Report Methods for Assessing Physical Activity in Epidemiologic Studies: Findings From the Women's Lifestyle Validation Study.

Among 683 participants in the Women's Lifestyle Validation Study (2010-2012), we evaluated the performance of a self-administered physical activity questionnaire (PAQ) and Web-based 24-hour recalls (Activities Completed Over Time in 24 Hours (ACT24)) using multiple comparison methods. Two PAQs, 4 ACT24s, two 7-day accelerometer measurements, 1 doubly labeled water (DLW) physical activity level (PAL) measure (repeated; n = 90), and 4 resting pulse rate measurements were collected over 15 months. The deattenuated correlation between the PAQ and DLW PAL was 0.

Elementary School Personnel and Cultural Factors Affecting Health Education Implementation in the High-Stakes Testing Era.

Background: Despite proven health and learning benefits, health education implementation in elementary schools is not optimal. This study investigated learning environment, leadership, and training factors that may influence elementary-level health education implementation in the current standardized testing-saturated environment.

Methods: Survey data were collected from principals of 8 Michigan elementary schools and, via focus groups, 30 teachers in their schools.

Method used to identify adenomyosis and potentially undiagnosed adenomyosis in a large, U.S. electronic health record database.

Background: The prevalence of adenomyosis is underestimated due to lack of a specific diagnostic code and diagnostic delays given most diagnoses occur at hysterectomy.

Objectives: To identify women with adenomyosis using indicators derived from natural language processing (NLP) of clinical notes in the Optum Electronic Health Record database (2014-2018), and to estimate the prevalence of potentially undiagnosed adenomyosis.

Methods: An NLP algorithm identified mentions of adenomyosis in clinical notes that were highly likely to represent a diagnosis.

The association of depression stigma with barriers to seeking mental health care: a cross-sectional analysis.

Stigma is one of several barriers to seeking mental health care. However, few studies have examined how stigma relates to other common barriers (e.g.

Objective and Self-Reported Measures of Physical Activity and Sex Hormones: Women's Lifestyle Validation Study.

: The relationship between specific characteristics of physical activity (PA) (eg, intensity, type, frequency) with sex hormones is uncertain. The authors evaluated the association between characteristics of PA and circulating sex hormones. : This was a cross-sectional analysis of the Women's Lifestyle Validation Study (n = 493).

Differentiating Between Walking and Stair Climbing Using Raw Accelerometry Data.

Wearable accelerometers provide an objective measure of human physical activity. They record high frequency unlabeled three-dimensional time series data. We extract meaningful features from the raw accelerometry data and based on them develop and evaluate a classification method for the detection of walking and its sub-classes, i.

Physical Activity and Incidence of Heart Failure in Postmenopausal Women.

Objectives: This study prospectively examined physical activity levels and the incidence of heart failure (HF) in 137,303 women, ages 50 to 79 years, and examined a subset of 35,272 women who, it was determined, had HF with preserved ejection fraction (HFpEF) and HF with reduced EF (HFrEF).

Background: The role of physical activity in HF risk among older women is unclear, particularly for incidence of HFpEF or HFrEF.

Methods: Women were free of HF and reported ability to walk at least 1 block without assistance at baseline.

Adolescent Weight and Electronic Vapor Product Use: Comparing BMI-Based With Perceived Weight Status.

Introduction: This study examined the associations of BMI-based and perceived body weight status with electronic vapor product use, cigarette smoking, and dual use among U.S. adolescents.

Associations of Sedentary Time with Energy Expenditure and Anthropometric Measures.

Purpose: To investigate associations between accelerometer-determined sedentary time (ST) in prolonged (≥30 min) and nonprolonged (<30 min) bouts with physical activity energy expenditure (PAEE) from doubly labeled water. Additionally, associations between ST and body mass index (BMI) and waist circumference were examined.

Methods: Data from 736 women and 655 men age 43 to 82 yr were analyzed.

They Shall Be One: Sexual Satisfaction Among Men and Women Married in the LDS Faith.

Sexual satisfaction is understudied among highly religious communities, such as the Church of Jesus Christ of Latter-day Saints (LDS). Through an Internet-based self-report survey, this study ( = 266) examined potential predictors of sexual satisfaction among adults living in Utah who had married in the LDS faith, regardless of current faith practice. Both men and women reported their perceived partner satisfaction as the top contributing factor to their own overall sexual satisfaction.

Balance- and Strength-Training Protocols to Improve Chronic Ankle Instability Deficits, Part II: Assessing Patient-Reported Outcome Measures.

Context:   Assessing global, regional, and fear-of-reinjury outcomes in individuals with chronic ankle instability (CAI) is critical to understanding the effectiveness of clinical interventions.

Objective:   To determine the improvement of patient-reported outcomes after balance- and strength-training and control protocols among participants with CAI.

Design:   Randomized controlled clinical trial.

Balance- and Strength-Training Protocols to Improve Chronic Ankle Instability Deficits, Part I: Assessing Clinical Outcome Measures.

Context:   Functional rehabilitation may improve the deficits associated with chronic ankle instability (CAI).

Objective:   To determine if balance- and strength-training protocols improve the balance, strength, and functional performance deficits associated with CAI.

Design:   Randomized controlled clinical trial.

Physical Activity and Incident Cardiovascular Disease in Women: Is the Relation Modified by Level of Global Cardiovascular Risk?

Background: The inverse association between physical activity and cardiovascular disease (CVD) is well- established and has previously been shown in people with and without single CVD risk factors. We examined whether level of global cardiovascular risk, on the basis of the pooled cohort equation or Reynolds risk score, which include multiple risk factors, modified the physical activity-CVD association.

Methods And Results: Participants in the prospective WHS (Women's Health Study; n=27 536) reported their leisure-time physical activity at study entry (1992-1995) and during follow-up through 2013.

Physical Wellness Among Gaming Adults: Cross-Sectional Study.

Background: Video and hobby gaming are immensely popular among adults; however, associations between gaming and health have primarily been investigated in children and adolescents. Furthermore, most research has focused on electronic gaming, despite traditional hobby gaming gaining prominence.

Objective: To determine whether the number of platforms used, platform preference, and gaming time are associated with obesity, physical activity, sedentary behavior, and cardiovascular risk factors in an adult gaming population.

BMI and Central Obesity With Falls Among Community-Dwelling Older Adults.

Introduction: This study examined the associations of BMI category and central obesity status, with falls among community-dwelling older adults in the U.S.

Methods: Data were drawn from the 2012 and 2014 U.

Time Spent Sitting as an Independent Risk Factor for Cardiovascular Disease.

Sedentary behavior is highly prevalent despite growing evidence of adverse effects on the cardiovascular and metabolic system that are independent of the level of recreational physical activity (PA). We present results for the association between sitting time and cardiovascular disease (CVD) from selected cohort and cross-sectional studies published in or after the year 2010 according to the domains where sitting time is accumulated during the day. These include TV viewing, occupational sitting, and sitting during transportation as well as overall sitting.

Association of physical activity and sitting time with incident colorectal cancer in postmenopausal women.

Findings from epidemiological studies have found that physical activity (PA) is associated with a lower risk of colorectal cancer (CRC). Recent studies have found an increased CRC risk with higher sitting time (ST); however, many studies did not include PA as a potential confounder. The objective of this project was to investigate the independent and combined associations of ST and PA with the risk of incident CRC, specifically colon and rectal cancer.