Texture analysis as a tool to study the kinetics of wet agglomeration processes.

In this work wet granulation experiments were carried out in a planetary mixer with the aim to develop a novel analytical tool based on surface texture analysis. The evolution of a simple formulation (300g of microcrystalline cellulose with a solid binders pre-dispersed in water) was monitored from the very beginning up to the end point and information on the kinetics of granulation as well as on the effect of liquid binder amount were collected. Agreement between texture analysis and granules particle size distribution obtained by sieving analysis was always found.

Scaling laws for the slip velocity in dense granular flows.

In this Letter, the two-dimensional dense flow of polygonal particles on an incline with a flat frictional inferior boundary is analyzed by means of contact dynamics discrete element simulations, in order to develop boundary conditions for continuum models of dense granular flows. We show the evidence that the global slip phenomenon deviates significantly from simple sliding: a finite slip velocity is generally found for shear forces lower than the sliding threshold for particle-wall contacts. We determined simple scaling laws for the dependence of the slip velocity on shear rate, normal and shear stresses, and material parameters.

Combining formulation and process aspects for optimizing the high-shear wet granulation of common drugs.

The purpose of this research was to determine the effects of some important drug properties (such as particle size distribution, hygroscopicity and solubility) and process variables on the granule growth behaviour and final drug distribution in high shear wet granulation. Results have been analyzed in the light of widely accepted theories and some recently developed approaches. A mixture composed of drug, some excipients and a dry binder was processed using a lab-scale high-shear mixer.

Formulation design for optimal high-shear wet granulation using on-line torque measurements.

An alternative procedure for achieving formulation design in a high-shear wet granulation process has been developed. Particularly, a new formulation map has been proposed which describes the onset of a significant granule growth as a function of the formulation variables (diluent, dry and liquid binder). Granule growth has been monitored using on-line impeller torque and evaluated as changes in granule particle size distribution with respect to the dry formulation.