Publications by authors named "Andrea Bottazzi"

Totally implanted venous access ports (TIVAPs) have been established as effective and safe devices for oncologic patients. In breast cancer setting, the implant of the reservoir at mid-arm allows the absence of additional scars on the chest and the easier access to the port with significant cosmetic and psychological advantages. In the last decades, breast surgery has made great progresses to ameliorate the cosmetic results even in mastectomy techniques.

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Donation after circulatory death (DCD) allows expansion of the donor pool. We report on 11 years of Italian experience by comparing the outcome of grafts from DCD and extracorporeal membrane oxygenation (ECMO) prior to death donation (EPD), a new donor category. We studied 58 kidney recipients from DCD or EPD and collected donor/recipient clinical characteristics.

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Background: A favourable attitude towards organ donation and transplantation is fundamental among health professionals to promote consent, especially in a young healthcare system like Albania.

Objective: To analyse the differences in the attitude towards organ donation and transplantation and the influencing factors among medical doctors- and nurses-to-be.

Methods And Design: The article is based on an observational, descriptive, cross-sectional study.

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Article Synopsis
  • Severe COVID-19 is linked to an imbalance in immune responses, specifically involving interferons (IFNs) types I and III, which play controversial roles in the disease's progression.
  • Research found that high levels of IFN-III, particularly in the upper airways, are associated with high viral loads but less severe disease, indicating a protective effect.
  • In contrast, severe cases show an overproduction of IFNs in the lower airways, linked to harmful gene pathways that increase cell death and reduce cell growth.
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Donations after circulatory death (DCD) are still challenging in Italy because of prolonged ischemia time (tWIT) due to the law and logistical issues. This cohort study was primarily aimed at assessing the association between successful transplantation and DCD types in the North Italy Transplant program. Adjusted risk ratios (RR) and 95% confidence intervals (CIs) for type III versus type II DCD were estimated using a Poisson regression model with a robust error variance.

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Article Synopsis
  • - The COVID-19 pandemic has led to over 2.5 million deaths, often due to an excessive immune response, particularly involving immune mediators whose details are still unclear.
  • - Interferons (IFNs), specifically type I (IFN-I) and type III (IFN-III), are important antiviral agents, but their effectiveness and role in managing COVID-19 are still under discussion.
  • - Research indicates that IFN-III is found in higher amounts in the lower airways of severe COVID-19 patients, while the upper airways of patients with high viral loads but milder disease show increased levels of both IFN-I and IFN-III, suggesting that these IFNs may have opposing effects depending on
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We describe the first case of acute cardiac injury directly linked to myocardial localization of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a 69-year-old patient with flu-like symptoms rapidly degenerating into respiratory distress, hypotension, and cardiogenic shock. The patient was successfully treated with venous-arterial extracorporeal membrane oxygenation (ECMO) and mechanical ventilation. Cardiac function fully recovered in 5 days and ECMO was removed.

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Background: Post-traumatic cerebral infarction (PTCI) is common after traumatic brain injury (TBI). It is unclear what the occurrence of a PTCI is, how it impacts the long-term outcome, and whether it adds incremental prognostic value to established outcome predictors.

Methods: This was a prospective multicenter cohort study of moderate and severe TBI patients.

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Introduction: Providing peripheral intravenous access is one of the most commonly performed technical procedures in hospitals and it is mandatory for all patients undergoing surgery. Obtaining peripheral intravenous access may be difficult and this may cause delays in patient management, increased risk of adverse events and hospitalization costs. The aim of this study is to develop and validate a scale to identify patients at risk of peripheral difficult intravenous access, applicable to any adult patient undergoing surgery.

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We report the case of a catheter-related bloodstream infection caused by Chryseobacterium indologenes, an uncommon and multi-resistant pathogen, in a pediatric patient with a long-term vascular access device placed for chemotherapy treatment. The infection was successfully treated with ciprofloxacin antibiotic-lock therapy. This is the first report on successful salvage of a long-term device colonized by multi-resistant Chryseobacterium indologenes.

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Article Synopsis
  • West syndrome is a rare infantile epilepsy characterized by spasms, specific brain wave patterns (hypsarrhythmia), and significant developmental delays.
  • Current first-line treatment is adrenocorticotropic hormone (ACTH), but it can lead to serious side effects.
  • A case study reports a patient developing diabetes mellitus and other complications during ACTH therapy, highlighting the importance of monitoring blood sugar levels throughout treatment.
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