Integrated Assessment of Coronary Physiology Based on Coronary Angiography in Heart Transplant Patients.

Background: Early detection of cardiac allograft vasculopathy after heart transplant (HTx) with invasive coronary angiography is challenging.

Aims: The study aimed to determine if computational techniques able to assess epicardial lesions, by means of Murray's law-based quantitative flow ratio (μFR), and microvascular physiology, by means of angiography microvascular resistance (AMR), enhance risk stratification in HTx patients with nonsignificant coronary artery disease.

Methods: The cohort consisted of 86 consecutive HTx patients (200 epicardial vessels) with stenosis < 50% at baseline.

Clinical Updates in Coronary Artery Disease: A Comprehensive Review.

Despite significant goals achieved in diagnosis and treatment in recent decades, coronary artery disease (CAD) remains a high mortality entity and continues to pose substantial challenges to healthcare systems globally. After the latest guidelines, novel data have emerged and have not been yet considered for routine practice. The scope of this review is to go beyond the guidelines, providing insights into the most recent clinical updates in CAD, focusing on non-invasive diagnostic techniques, risk stratification, medical management and interventional therapies in the acute and stable scenarios.