Publications by authors named "Andrea Borenich"
Background: Factor XIII plays a key role within the coagulation cascade.
Objective: We aimed to investigate the relevance of factor XIII activity on the outcome of patients with gastrointestinal bleedings.
Methods: In this retrospective, single-center study patients with gastrointestinal bleeding and measurement of factor XIII activity were included.
Article Synopsis
- Chronic kidney disease (CKD) patients often have lower activity of lecithin-cholesterol acyltransferase (LCAT), which is crucial for high-density lipoprotein (HDL) maturation and may raise cardiovascular mortality risk.
- A study involving 453 non-dialysis CKD patients showed a direct correlation between LCAT activity and smaller, potentially protective HDL particle sizes.
- The research found that lower LCAT activity was significantly linked to higher risks of all-cause mortality and acute decompensated heart failure, but not to other cardiovascular events or kidney function decline over a 5-year follow-up.
Background: To ensure a safe patient discharge from hospital it is necessary to transfer all relevant information in a discharge summary (DS). The aim of this study was to evaluate a bundle of measures to improve the DS for physicians, nurses and patients.
Methods: In a double-blind, randomized, controlled trial, four different versions of DS (2 original, 2 revised) were tested with physicians, nurses and patients.
Background: Non-alcoholic fatty liver disease (NAFLD) is increasing worldwide. A main cause is the obesogenic, so-called Western lifestyle. NAFLD follows a long, unperceived course, and ends potentially fatally.
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- Vaccination hesitancy among patients on chronic hemodialysis has increased during the COVID-19 pandemic, highlighting the need for strategies to address concerns and improve vaccination rates.
- A study involving 347 hemodialysis patients in Austria found that older patients preferred information from dialysis physicians, while younger patients were more likely to rely on online sources for vaccine information.
- Although 86% of patients expressed a desire to complete vaccinations, only 39% felt adequately informed about the vaccination plan, indicating a significant gap in knowledge that needs to be addressed.
Purpose: The aim of this prospective longitudinal study was to assess both subjective quality of life using questionnaires and objective examination of nasal function with regard to olfaction, nasal air flow and mucociliary clearance in patients after minimally invasive, turbinate-preserving endoscopic transnasal trans-sphenoidal pituitary surgery.
Methods: Patients undergoing endoscopic transnasal pituitary surgery were recruited prospectively and examined during three study visits, preoperatively and 3 and 6 months postoperatively. We examined nasal function using sniffin' sticks test, rhinomanometry, saccharin transit time test, and endoscopic and radiological scores.
Health-related quality of life (HRQOL) improves after kidney transplantation (KT) but declines over time. Studies on the effect of early postoperative basal insulin therapy on HRQOL after KT, especially KTRs at high risk of developing post-transplant diabetes mellitus (PTDM) are missing. Data from a randomized controlled trial on 148 non-diabetic KTRs were analyzed.
View Article and Find Full Text PDFBackground: Among patients with ulcerative colitis, 30-50% receive corticosteroids within the first five years after diagnosis. We aimed to reconsider their effectiveness in the context of the biologic era.
Methods: In this prospective, multicenter study, patients with active ulcerative colitis (Lichtiger score ≥ 4) were eligible if initiating systemic corticosteroids.
Article Synopsis
- * Analyzed data from 116 patients showed a reoperation rate of 17.2%, with significantly higher rates (52.2%) in patients with displaced fractures compared to those with undisplaced ones (8.9%).
- * The findings suggest that while internal fixation is effective for undisplaced fractures, primary hip replacement may be preferable for displaced fractures due to the high reoperation risk.
Article Synopsis
- This study examines how various methods define the center of a keratoconus cone and analyzes inconsistencies among these definitions across tomographic maps.
- Researchers reviewed corneal tomographic data from 162 eyes with keratoconus using five different location-determining methods and measured the distances between each method's results.
- Findings indicate that curvature-based methods show significant discrepancies compared to elevation and pachymetry-based methods, with larger deviations linked to less severe keratoconus and more peripheral cone positions.
Background: With the experience-based hypothesis of low donor site morbidity (DSM) for free flaps from the distal femur, this cohort study aimed to evaluate the DSM according to objective and reproducible criteria.
Methods: One hundred and fifty-six patients who had a flap harvest from either the medial or lateral femoral condyle region between 2005 and 2017 were included. A retrospective chart review was performed for all patients.
(1): Heart rate performance curve (HRPC) in incremental exercise was shown to be not uniform, causing false intensity estimation applying percentages of maximal heart rate (HR). HRPC variations are mediated by β-adrenergic receptor sensitivity. The aim was to study age and sex dependent differences in HRPC patterns in adults with β-blocker treatment (BB) and healthy controls (C).
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- Anti-TNF antibodies are the first biologic treatment option for inflammatory bowel diseases, with a study assessing their treatment persistence over 20 years.
- In a study of 538 patients, treatment persistence was found to be low, with a median of only 2.3 years, and notable differences based on gender and type of disease (Crohn's vs. ulcerative colitis).
- The main reasons for discontinuing treatment were treatment failure (52%) and side effects (25%), with female patients showing a higher risk of treatment failure in those with ulcerative colitis.
Low prevalence of gastroesophageal reflux symptoms in vegetarians.
Indian J Gastroenterol
April 2021
Background: Dietary modification could reduce the risk of gastroesophageal reflux disease. Circumstantial evidence suggests that gastroesophageal reflux is less prevalent in people adhering to a vegetarian diet. We aimed to study the relationship between vegetarianism and the occurrence of gastroesophageal reflux symptoms (GERS).
View Article and Find Full Text PDFGlioblastoma (GBM) is an utterly devastating cerebral neoplasm and current therapies only marginally improve patients' overall survival (OS). The PI3K/AKT/mTOR pathway participates in gliomagenesis through regulation of cell growth and proliferation. Since it is an upstream regulator of the rate-limiting translation initiation step of protein synthesis, controlled by eukaryotic initiation factors (eIFs), we aimed for a profound basic characterization of 17 eIFs to identify potential novel therapeutic targets for gliomas.
View Article and Find Full Text PDFIntroduction: Morbidity and mortality conferences (M&MCs) are an instrument for learning from past complications, unexpected follow-ups and deaths in hospitals and are important for improving patient safety. However, there are currently no quantitative data on the implementation of M&MCs in Austria. The aim of the study was to determine the status quo of the M&MCs in Austria.
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- * A study found that obese women showed significant changes in HDL composition and function, including lower levels of key components and a shift towards smaller HDL subtypes, which may increase cardiovascular risk.
- * The findings suggest that obesity disrupts HDL metabolism and may elevate cardiovascular risk through mechanisms involving liver and fat tissue changes, particularly affecting obese women more than those who are simply overweight.
The Heart Rate Performance Curve (HRPC) is neither linear nor uniform and related to ß1-adrenoceptor sensitivity. As aging and exercise influence ß1-adrenoceptors we suggested age, sex and performance effects on the HRPC. Aim of the study was to examine the effects of aging on the deflection of the HRPC in maximal incremental cycle ergometer exercise (CE) in a large cohort of healthy subjects.
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