A novel LAMA3 mutation in a newborn with junctional epidermolysis bullosa herlitz type.

The case of a male neonate of 41 weeks' gestation who developed blistering of the skin immediately after birth is described. His parents were consanguineous Tunisians. Electron microscopy of a cutaneous biopsy showed skin cleavage within the lamina lucida and immunoepitope mapping revealed a complete absence of laminin 332 expression.

[Topic efficacy of ialuronic acid associated with argentic sulphadiazine (Connettivina Plus) in the treatment of pressure sores: a prospective observational cohort study].

Rationale: The aim of this observational study was to evaluate the efficacy, tolerability and methods of application of ialuronic acid associated with argentic sulphadiazine (Connettivina Plus) in routine clinical activity, on a target of "complex" patients with pressure sores, for the most realistic assessment possible. The study comprised 127 patients hospitalized between January 2006 and December 2007, who received ialuronic acid associated with argentic sulphadiazine in addition to the standard treatment. Inclusion criteria were th presence of at least one stage 2 or 3 pressure sore (NPUAP '89 classification), pressure sore that the researcher had already decided to treat using ialuronic acid associated with argentic sulphadiazine , according to hospital protocol, area of the lesion less than 25cm2, patient age 18 years or more, informed patient consensus.

[Two years of randomized and controlled clinical studies on pressure ulcers: does it change anything in the A.H.C.P.R. guidelines?].

The problem of the pressure ulcers is today one of the critical and controversial appearance of nursing. To use A.H.