A novel animal model of severe pancreatitis in mice and its differences to the rat.

Background: A noninvasive model of necrohemorrhagic pancreatitis induced by simultaneous intravenous cerulein/enterokinase (EK) infusion has recently been established in rats. The aim of the present study was to establish this new model in mice and to compare it with the rat model.

Methods: Male Balb/C mice (20 to 25 g) were used for the experiments.