Publications by authors named "Andrea B Sedlock"
Microglia are resident inflammatory cells of the CNS and have important roles in development, homeostasis and a variety of neurologic and psychiatric diseases. Difficulties in procuring human microglia have limited their study and hampered the clinical translation of microglia-based treatments shown to be effective in animal disease models. Here we report the differentiation of human induced pluripotent stem cells (iPSC) into microglia-like cells by exposure to defined factors and co-culture with astrocytes.
View Article and Find Full Text PDFNeotyphodium species are fungal endophytes best known for their protection of grass hosts and production of bioactive metabolites including ergot alkaloids. Perennial ryegrass-Neotyphodium sp. Lp1 symbiota that have altered ergot alkaloid profiles (resulting from knockouts in two different endophyte genes) were fed, along with controls, to rabbits to test the effects of ergot alkaloids on food preference and satiety.
View Article and Find Full Text PDFArticle Synopsis
- Scientists studied a special enzyme called Lysergyl peptide synthetase 1 that helps make toxic substances called ergopeptines from a type of acid and three amino acids.
- They compared the gene that makes this enzyme in two different fungi: Neotyphodium lolii and Claviceps purpurea, and found some similarities and differences in their genes.
- The study also discovered other related fungi with similar genes, including a different version of the enzyme in another fungus that helps grass grow better.