Publications by authors named "Andrea A Carter"
Article Synopsis
- The Notch signaling pathway is crucial for determining cell fate and is influenced by the ubiquitin ligase Deltex.
- Using NMR spectroscopy, researchers identified how Deltex interacts with the Notch ankyrin (ANK) domain, highlighting the N-terminal WWE motif as the binding site.
- Mutations in either Deltex or ANK disrupt their interaction and the enhancement of Notch transcriptional activation, while an unexpected finding reveals that Deltex can still bind to the Notch intracellular domain without its WWE domain, indicating a potential secondary interaction.
