Publications by authors named "Andre-Caroli Rocha"

Article Synopsis
  • Medication-related osteonecrosis of the jaw (MRONJ) is a serious condition that can lead to severe bone loss, making diagnosis difficult, especially in patients receiving certain cancer treatments.* -
  • A case study of a 68-year-old man with liver cancer showed symptoms of jaw pain, yet initial dental exams revealed no obvious issues until deeper investigation indicated MRONJ Stage 2.* -
  • After surgical treatment for MRONJ, the patient experienced relief, highlighting the importance of considering MRONJ in patients with jaw pain who are undergoing specific therapies, as well as the need for careful monitoring of dental health in these individuals.*
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Benign peripheral nerve sheath tumors (BPNSTs) are a vast, common, heterogeneous group of lesions that are often diagnostically challenging. The head and neck region is recognized as the second most common location for these lesions, especially the tongue. However, BPNSTs occurring centrally within the jaw bones are exceedingly rare.

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Intravascular papillary endothelial hyperplasia (IPEH) represents an uncommon reactive endothelial hyperplastic proliferation. A 46-year-old man experienced increased volume in the right maxilla, elevation of the nasal ala, and swelling of the hard palate with a reddish hue for 3 months. Computed tomography revealed an expansive hypodense region and cortical bone destruction associated with an impacted supernumerary tooth and an endodontically treated tooth.

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In the modern world, cancer is a growing cause of mortality, but archeological studies have shown that it is not exclusive to modern populations. The aim of this study is to examine the epidemiologic, social, and clinicopathologic features of head and neck cancers in ancient populations. To do this, we extracted all records that described malignant lesions in the head and neck region available in the Cancer Research in Ancient Bodies Database (CRAB).

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Background: Ameloblastoma and ameloblastic carcinoma are epithelial odontogenic tumors that can be morphologically similar. In the present study, we evaluated the DNA content and Ki-67 index in the two tumors.

Methods: The paraffin blocks of the tumors were selected to obtain sections for the immunohistochemical reactions and preparation of the cell suspension for acquisition in a flow cytometer.

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Objective: The aim of this study was to evaluate the clinical outcomes of dental implants (DIs) in patients with head and neck cancer (HNC) treated with radiotherapy (RT), isolated chemotherapy, or bone modifying agents (BMAs).

Study Design: This study was registered in the Prospective Register of Systematic Reviews (CRD42018102772); conducted via the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist; and based on PubMed, Scopus, Embase, Cochrane Library, Web of Science, and gray literature searches. The selection of studies was performed in 2 phases by 2 independent reviewers.

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Purpose: This systematic review aimed to determine whether the pentoxifylline and tocopherol (PENTO) protocol effectively reduce the risk of osteoradionecrosis (ORN) in patients undergoing tooth extraction after head and neck radiotherapy.

Methods: We searched PubMed, SCOPUS, LILACS, EMBASE, Web of Science, and Cochrane databases up to August 2022. We considered only studies that included patients diagnosed with head and neck cancer undergoing tooth extraction with PENTO prophylaxis after radiotherapy.

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The aim of this study is to report an original case series of synchronous jawbone diseases. Data of patients seen over 13 years were extracted from the files of three Oral Radiology and Pathology diagnostic centers in Brazil. The clinical, radiographic, and laboratory characteristics were tabulated and analyzed by the authors; the patients were described according to lesion type.

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The differentiation between ameloblastoma (AB) and odontogenic keratocyst (OKC) is essential for the formulation of the surgical plan, especially considering the biological behavior of these two pathological entities. Therefore, developing means to increase the accuracy of the diagnostic process is extremely important for a safe treatment. The aim of this study was to use magnetic resonance imaging (MRI) based on texture analysis (TA) as an aid in differentiating AB from OKC.

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Background: Rhabdomyosarcoma (RMS) harboring EWSR1/FUS-TFCP2 fusions has been recently described as a distinct form of RMS with an aggressive course and predilection for the craniofacial bones, especially the jaws.

Methods: We report three new cases of this rare entity, two from Brazil and one from Guatemala, with detailed clinicopathologic, immunohistochemical, and molecular descriptions. Additionally, we explored the English-language literature searching RMS with TFCP2 rearrangement or typical immunophenotype with co-expression of AE1/AE3 and ALK in the head and neck region.

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Purpose: Teeth with poor prognosis are generally recommended to be extracted prior to head and neck radiotherapy (RT) to reduce the risk of developing osteoradionecrosis (ORN), although controversies have been reported. The present systematic review aimed to determine whether tooth extraction prior to head and neck RT may be associated with a reduced risk of developing ORN compared to dental extraction during or after RT.

Methods: The review protocol was registered in PROSPERO (CRD42021241631).

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Objectives: The aim of the current study was to analyse the demographic, clinical and radiological features of primary aneurysmal bone cysts (ABCs) involving the maxillofacial region.

Methods: Histologically confirmed cases affecting the maxillofacial region were retrospectively reviewed over a 21-year period (2000-2021). Cases were collected from the archives of five Oral Pathology laboratories from three countries: South Africa, Guatemala and Brazil.

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Purpose: This study aimed to analyze the impact of surgical treatment on the quality of life of patients diagnosed with ameloblastoma.

Methods: We searched PubMed, Science Direct, LILACS, EMBASE, and Web of Science, up to February 2021, with no time restriction. We considered only studies published in English that evaluated patients diagnosed with ameloblastoma who underwent conservative or radical surgical treatments using a quality of life (QOL) instrument.

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Article Synopsis
  • This review examines the development and current status of oral medicine (stomatology) in Brazil, referencing the Brazilian Society of Stomatology and Oral Pathology (SOBEP) and the Federal Dental Council.
  • Oral medicine in Brazil began in 1969 with SOBEP founded in 1974, but only became officially recognized as a specialty in 1992.
  • After 50 years of growth, the field is now focusing on aligning with international trends and creating a standardized postgraduate curriculum for training oral medicine specialists in Brazil.
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  • - The study investigates the expression of DNA methyltransferases (DNMTs) and histone modification (H3K9ac) in different dental tissue types (dental follicle, ameloblastoma, and ameloblastic carcinoma) to understand their role in recurrence and aggressive behavior in ameloblastoma.
  • - Immunohistochemical analysis of samples revealed higher DNMT3B expression in ameloblastomas compared to dental follicles, while ameloblastic carcinoma showed overexpression of all proteins studied.
  • - The research highlights that DNMT1 was overexpressed in specific aggressive cases, while recurrent ameloblastomas had elevated DNMT3B levels, suggesting that DNA methylation and histone modification are important factors in the clinical
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Ameloblastoma is a benign, but locally aggressive odontogenic neoplasm, whose appropriate therapeutic management remains highly debatable. The aim of this study was to evaluate the reliability and effectiveness of the two conservative surgical therapeutic protocols (curettage with peripheral ostectomy only and curettage plus cryotherapy) for the management of ameloblastomas. About 53 cases of the ameloblastomas treated in 9 years were retrospectively analyzed regarding their clinical, histopathologic, radiographic, and therapeutic data.

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Brain abscesses due to odontogenic infection are infrequent, but they deserve attention due to the high incidence of serious complications and the high mortality rate. This article aimed to report five cases of cerebral abscess due to odontogenic infection, of patients attended in the Clinical Hospital of Medical School of the University of São Paulo (HCFMUSP). In all cases, treatment consisted of draining the brain abscess, antibiotic therapy and extraction of all teeth responsible for the infection.

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Several treatment protocols for medication-related osteonecrosis of the jaw (MRONJ) have been published. Despite the efficacy of surgical therapy of approximately 90% as primary therapy, the role of other agents, such as drug administration, should not be underestimated. Based on previous experience with osteoradionecrosis, the association of pentoxifylline and tocopherol has shown encouraging results in MRONJ patients.

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The Numb Chin Syndrome (NCS) is defined as facial and oral numbness restricted to the mental nerve's distribution involving the lower lip, skin of the chin, or gingiva of the lower anterior teeth. Hypoesthesia can occur unilaterally or bilaterally. Although this syndrome is rare, its importance is related to the fact that it represents the clinical manifestations of malignant diseases.

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Article Synopsis
  • - The study focused on Burkitt lymphoma affecting the head and neck (BLHN) in pediatric patients from Africa, Guatemala, and Brazil, revealing common clinical and anatomical characteristics across these regions.
  • - Among the 52 cases reviewed, a significant majority (82.69%) were children, with common symptoms including tumors, cervical lymphadenopathy, and bone destruction, and typical features associated with Burkitt lymphoma were observed.
  • - Immunohistochemical analysis showed uniform expression of specific markers like CD20 and high Ki-67 indices, with Epstein-Barr virus (EBV) present in about 62% of cases, indicating similarities in the disease profile across the studied populations.
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Article Synopsis
  • Antiresorptive therapy is crucial for preventing osteoporotic fractures, but it can lead to a serious side effect known as medication-related osteonecrosis of the jaw (MRONJ).
  • A task force reviewed the risk factors and prevention strategies for MRONJ in patients with osteoporosis who need dental work, emphasizing the need for caution among healthcare providers.
  • Although MRONJ is rare in these patients, its severity and impact on quality of life make it essential to weigh the risks before proceeding with invasive dental procedures.
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Objectives: Ameloblastoma is an odontogenic epithelial tumour with a low expression of mismatch repair system components. We aimed to investigate the methylation status of the genes MSH2, MSH3 and MSH6 (MutS group) in conventional ameloblastomas.

Materials And Methods: The ameloblastoma and dental follicle samples (n = 10 each) were collected from 20 different patients.

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Article Synopsis
  • * After successful treatment with denosumab, she experienced a temporary case of osteonecrosis in the jaw, which resolved with antibiotics.
  • * However, following a maxillary surgery six months after stopping denosumab, she developed severe rebound hypercalcemia that required intensive medical treatment, but after two years, she remains healthy with no recurrences.
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