Publications by authors named "Andre da Costa Ferreira"
Nitric Oxide
December 2024
Article Synopsis
- The role of nitric oxide (NO) in cerebral malaria is debated, and its associated cognitive impairments highlight the need for new therapies to prevent long-term effects after recovery from Plasmodium falciparum infection.
- Elevated nitric oxide levels from the enzyme inducible nitric oxide synthase (iNOS) may lead to neurological damage and cognitive decline through harmful nitrogen-reactive intermediates, necessitating research into its impact.
- Studies in mice treated with aminoguanidine (an iNOS inhibitor) or lacking the iNOS enzyme showed reduced signs of cerebral malaria and improved cognitive function, emphasizing the potential benefits of targeting iNOS to mitigate both the disease and its long-term cognitive effects.
