Publications by authors named "Andre Warnke"
Article Synopsis
- The study aimed to compare the skin adhesion of a new rotigotine transdermal patch (ROT-TDS) to an existing product for patients with Parkinson's disease (PD).
- Research included pharmacokinetic testing on healthy adults and a trial on PD patients to assess adhesion and safety.
- Results showed that ROT-TDS had similar effectiveness and safety as the reference patch but also demonstrated better skin adhesion, with a higher percentage of patches staying adhered through the dosing period.
Article Synopsis
- - The study tested the pharmacokinetics of tolterodine from vaginal rings versus oral extended-release tolterodine in healthy postmenopausal women, focusing on its active metabolite 5-hydroxymethyl tolterodine (5-HMT).
- - Results showed that while oral administration caused significant fluctuations in drug plasma levels, the vaginal rings provided steadier concentrations over time due to their constant release rates.
- - Both formulations were well-tolerated, with common side effects being headaches and dry mouth, but the vaginal rings are seen as a promising option for treating overactive bladder with potentially fewer side effects and more consistent therapeutic effects.
Article Synopsis
- The study aimed to establish the bioavailability and bioequivalence of oral, immediate-release tablets containing pridinol through a randomized trial with healthy adult subjects.
- A total of 34 participants received both test and reference products, and pharmacokinetic evaluations showed similar absorption rates and durations for both formulations.
- The results confirmed the bioequivalence of the two pridinol products, with safety profiles consistent with previous knowledge about the drug's side effects.
Single-dose pharmacokinetics and pharmacodynamics assessment of oestriol and trimegestone containing vaginal rings in healthy women with childbearing potential.
Natalícia de Jesus Antunes Raimundo Vieira de Oliveira Filho Jaime de Oliveira Ilha Ronilson A Moreno André Felipe Nahoum André Warnke
Eur J Contracept Reprod Health Care
June 2021
Article Synopsis
- - The study aimed to analyze how well oestriol (E3) and trimegestone (TMG) are absorbed and work in the body when delivered via three different vaginal rings over 21 days, each with varying doses of E3/TMG.
- - Thirty-five healthy women participated, receiving one of the three test rings, while blood samples measured hormone levels and safety was monitored through adverse events.
- - Results showed that the third test ring provided the best balance of E3/TMG for preventing bleeding and achieving contraception, with all rings being well tolerated by participants.
Article Synopsis
- - The study aimed to determine how well trazodone and gabapentin maintain proportionality at specific fixed doses (2.5/25, 10/100, and 30/300) and to check for any drug-drug interactions at the 10/100 dose.
- - Conducted with 29 healthy participants in a single-center trial, the research involved blood sampling and analysis using a validated LC-MS/MS method to measure drug levels, with no serious adverse events reported.
- - Findings revealed that trazodone's plasma concentration showed proportionality across all doses, while gabapentin was only proportional from 25 to 100 mg, confirming that there was no significant interaction between the two drugs when combined. *
Pharmacokinetics and pharmacodynamics of three dosages of oestriol after continuous vaginal ring administration for 21 days in healthy, postmenopausal women.
Raimundo Vieira de Oliveira Filho Natalícia de Jesus Antunes Jaime de Oliveira Ilha Ronilson Agnaldo Moreno Ralph-Steven Wedemeyer André Warnke
Br J Clin Pharmacol
March 2019
Low-molecular-weight heparins (LMWHs) differ considerably in their influence on clotting tests and release of tissue factor pathway inhibitor (TFPI). Biosimilarity therefore becomes an issue when generic forms of LMWHs are developed. So far, no bioequivalence study with a generic LMWH has been reported.
View Article and Find Full Text PDFProton pump inhibitors are used extensively for the treatment of gastric acid-related disorders because they produce a greater degree and longer duration of gastric acid suppression and, thus, better healing rates, than histamine H(2) receptor antagonists. The need for long-term treatment of these disorders raises the potential for clinically significant drug interactions in patients receiving proton pump inhibitors and other medications. Therefore, it is important to understand the mechanisms for drug interactions in this setting.
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