Publications by authors named "Andre Walther"
Article Synopsis
- In response to DNA damage, cells activate two key processes: recognizing and repairing the damage, and temporarily halting the cell cycle for repair to take place.
- The protein complex Replication Protein A (RPA), particularly its 32-kDa subunit RPA2, plays a crucial role in the DNA-damage response, with focus on the N-terminal phosphorylation domain.
- Research using budding yeast showed that while the Rfa2 N-terminus is important for responding to DNA damage, its phosphorylation isn't necessary; however, modifications might affect whether cells continue dividing amidst unrepaired damage.
RAD53 and MEC1 are essential Saccharomyces cerevisiae genes required for the DNA replication and DNA damage checkpoint responses. Their lethality can be suppressed by increasing the intracellular pool of deoxynucleotide triphosphates. We report that deletion of YKU70 or YKU80 suppresses mec1Delta, but not rad53Delta, lethality.
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