Publications by authors named "Andre Rochet"
Background: Chronic inflammation is a key feature of obesity and a hallmark of colon cancer (CC). The obesity-related hormones leptin and adiponectin alter inflammatory gene profiles in cancer, but their specific role in CC is unclear. We have previously studied the effects of leptin and the macrophage-specific mediator itaconate on M2-like macrophages.
View Article and Find Full Text PDFThe NOTCH4-GATA4-IRG1 axis as a novel target in early-onset colorectal cancer.
Cytokine Growth Factor Rev
October 2022
The early onset of colorectal cancer (CRC) in individuals younger than 50 years is an emerging phenomenon, and obesity is a strong risk factor. Inflammatory mechanisms are mediated by immune cells, with macrophages and their phenotypical changes playing a significant role in CRC. Obesity-related hormones, such as leptin and adiponectin, affect macrophage polarization and cytokine expression.
View Article and Find Full Text PDFBackground: Colon cancer is a leading cause of cancer-related death. Long non-coding (Lnc) RNAs are critical mediators of tumor biology. H19 is a well-characterized lncRNA involved in p53 regulation and cancer progression.
View Article and Find Full Text PDFArticle Synopsis
- Colon adenocarcinoma is a leading cause of cancer deaths globally, with the epithelial-mesenchymal transition process playing a key role in cancer metastasis.
- An analysis identified the long non-coding RNA ZFAS1 as significantly elevated in colon cancer compared to normal tissue, and this was validated through further testing.
- ZFAS1 knockdown reduced cell proliferation, migration, and invasion in colon cancer cell lines, revealing its critical role in regulating the miR-200/ZEB1/E-cadherin and vimentin signaling pathway, with implications for tumor growth in vivo.