In vivo determination of the diclofenac skin reservoir: comparison between passive, occlusive, and iontophoretic application.

Aim: There is scarce information concerning the pharmacodynamic behavior of topical substances used in the physiotherapy setting. The aim of the present study was to estimate the formation and emptying of the diclofenac (DF) skin reservoir after passive, semiocclusive, and electrically assisted applications of DF.

Subjects And Methods: Five different groups of healthy volunteers (ntotal=60, 23 male and 37 female), participated in this study.