The "Prudente Plan:" a São Paulo plan for the fight against cancer in Brazil, 1934-1954.

This article investigates the strategies employed by Antônio Prudente to develop an initiative aimed at combating cancer throughout Brazil, based on his experience in the state of São Paulo. The approach used in the analysis draws on both the historiographical literature and primary sources, focusing on the period from 1934, when the São Paulo Association for the Fight against Cancer was founded, to 1954, when Prudente was appointed director of the National Cancer Service. The study highlights the disputes between cancerologists from the Union and São Paulo, highlighting the uniqueness of the São Paulo proposal, marked by a combination of liberal ideals and the sentiment of "Paulistaness.

Layer formation, morphology and photoluminescent properties of ultrasonic spray of pre-formed YVO:Eu and SiO coated ZnS:Mn nanoparticles.

In this work, we study the coating process and coating quality of photoluminescent particles deposited on a glass surface in terms of particle distribution and associated film continuity. The dispersion process of commercial ZnS:Mn particles and YVO:Eu particles synthesized by microwave reactor in aqueous solutions onto solid surface was performed using an ultrasonic atomizer. Two methods of particle deposition were used, one by moving the substrates while spraying and in the second the substrates were not moved.

Military Dictatorship and the Faculty of Medicine-USP: the Experimental Medicine Course, 1967-1982.

This article aimed to historically assess the impact undergone by the Faculty of Medicine-USP when it formally supported the military regime established in Brazil from 1964 onwards and the consequences of this support in its daily life. Another objective was unearthing how this context, lived between persecution, prisons, and torture, also intervened in didactic-pedagogical actions, such as the creation of a new model of medical education in 1967, known as the Experimental Course. This course would be immediately attacked by groups that saw it as a communist stronghold and a threat to the tradition of the so-called "Casa de Arnaldo", resulting in the closure of its activities in 1974.

Microbial Complexity of Oral Cavity of Healthy Dogs Identified by Mass Spectrometry and Next-Generation Sequencing.

The high complexity of the oral microbiota of healthy dogs and the close exposure of humans to companion animals represent a risk of the transmission of potential zoonotic microorganisms to humans, especially through dog bites, including multidrug-resistant ones. Nonetheless, a limited number of comprehensive studies have focused on the diversity of the microorganisms that inhabit the oral cavities of healthy dogs, particularly based on modern molecular techniques. We investigated bacterial and fungal organisms in the oral cavities of 100 healthy dogs based on a combination of conventional and selective microbiological culture, mass spectrometry (MALDI-TOF MS), and next-generation sequencing.

Ring Fracture of Brazilian Aortic Valve Bioprostheses Using Non-Compliant High-Pressure Transcatheter Balloon, an Ex Vivo Test.

Introduction: Aortic valve bioprostheses ring fracture in valve-in-valve procedures has shown low complication rates and presents as an option in the treatment of patients at high risk for conventional surgery, avoiding high transvalvular gradients, which are associated with increased mortality. Some prostheses available in the market cannot be fractured. In an ex vivo test, the possibility of ring fracture of aortic valve bioprostheses produced in Brazil when submitted to radial force application using a high-pressure non-compliant balloon was evaluated.

[The "Boletim da Clínica Psiquiátrica da FMUPS," 1962-1971: a forgotten publication and portrait of an era].

This article describes the Boletim da Clínica Psiquiátrica da Faculdade de Medicina da Universidade de São Paulo, which was published from 1962 to 1971. This was the first scientific publication of the Psychiatric Clinic, and was replaced by the Revista de Psiquiatria Clínica, which still exists today. The Boletim is a valuable source for historical research, spanning a decade of Brazilian psychiatry, and contains a variety of content: medication trials, theoretical discussions, current events, and institutional issues related to the development of psychiatry and related areas such as psychology and psychoanalysis, as well as the arrival of medications and the search for standardized diagnoses.

A "Dirty" Footprint: Macroinvertebrate diversity in Amazonian Anthropic Soils.

Amazonian rainforests, once thought to be pristine wilderness, are increasingly known to have been widely inhabited, modified, and managed prior to European arrival, by human populations with diverse cultural backgrounds. Amazonian Dark Earths (ADEs) are fertile soils found throughout the Amazon Basin, created by pre-Columbian societies with sedentary habits. Much is known about the chemistry of these soils, yet their zoology has been neglected.

Topical Delivery of Muscarinic Receptor Antagonists Prevents and Reverses Peripheral Neuropathy in Female Diabetic Mice.

Muscarinic antagonists promote sensory neurite outgrowth in vitro and prevent and/or reverse multiple indices of peripheral neuropathy in rodent models of diabetes, chemotherapy-induced peripheral neuropathy, and HIV protein-induced neuropathy when delivered systemically. We measured plasma concentrations of the M receptor-selective muscarinic antagonist pirenzepine when delivered by subcutaneous injection, oral gavage, or topical application to the skin and investigated efficacy of topically delivered pirenzepine against indices of peripheral neuropathy in diabetic mice. Topical application of 2% pirenzepine to the paw resulted in plasma concentrations 6 hours postdelivery that approximated those previously shown to promote neurite outgrowth in vitro.

Rhodococcus equi pVAPN type causing pneumonia in a dog coinfected with canine morbillivirus (distemper virus) and Toxoplasma gondii.

Canine morbillivirus (previously, canine distemper virus, CDV) is a highly contagious infectious disease-causing agent that produces immunosuppressive infections and multiple clinical signs. Canine toxoplasmosis is an opportunistic disease characterized by enteric, pulmonary, and neuromuscular signs that might be confused with CDV-induced infections. Rhodococcus equi is a Gram-positive intracellular facultative bacterium that is also opportunistic in nature, and causes pyogranulomatous infections in humans and multiple host animals, although canine rhodococcosis is rare or unrecognized.

Immunohistochemical Expression of Melatonin Receptor MT1 and Glucose Transporter GLUT1 in Human Breast Cancer.

Background: Breast cancer is a heterogeneous disease and is the leading cause of cancer-related deaths among women. Even after diagnosis, the prognosis cannot be concluded since patients can develop resistance to therapy, which favors tumor growth, invasion and metastasis. In recent years, research has focused on identifying significant markers that can be used to determine the prognosis.

Melatonin restrains angiogenic factors in triple-negative breast cancer by targeting miR-152-3p: In vivo and in vitro studies.

Aims: Breast cancer represents the second most prevalent tumor-related cause of death among women. Although studies have already been published regarding the association between breast tumors and miRNAs, this field remains unclear. MicroRNAs (miRNAs) are defined as non-coding RNA molecules, and are known to be involved in cell pathways through the regulation of gene expression.

[Spanish Flu in Sorocaba and the case of the Santa Rosália factory, 1918: local history contributions to the study of epidemics in Brazil].

An investigation is presented of the tensions that emerged during the Spanish flu epidemic in the city of Sorocaba, Brazil, between October and December 1918. It draws on previously unused primary sources, namely the narratives contained in the local press, taking the Santa Rosália factory as a case study, particularly its owner's refusal to maintain the work stoppage at the height of the epidemic, even when requested to by the municipal authority. This research contributes to the study of epidemics in Brazil's inland municipalities, emphasizing how local history can contribute to investigations of the history of disease in the country.

Molecular characterization of breast cancer cell lines by clinical immunohistochemical markers.

Breast cancer is the leading cause of cancer mortality in females worldwide. Studies based on gene expression profiles have identified different breast cancer molecular subtypes, such as luminal A and B cells, cancer cells that are estrogen receptor (ER) and/or progesterone receptor (PR) positive, human epidermal growth factor 2 (HER2)-enriched cells, cancer cells that exhibit an overexpression of the oncogene , and triple-negative cells, cancer cells that are negative for ER, PR and HER2 expression. Immunohistochemistry is the most common type of method used for the identification of these molecular subtypes, through the identification of specific cell receptors.

Effectiveness of Three Desensitizing Dentifrices on Cervical Dentin Hypersensitivity: A Pilot Clinical Trial.

Aim: Cervical dentin hypersensitivity (CDH) is defined as an acute pain of short duration that occurs in dentin exposed to the oral environment. The aim of this study was to evaluate the effi cacy of three desensitizing toothpastes (Sensodyne® Rapid-Relief, Colgate® Sensitive Pro-Relief, Nano P®) for immediate and intermediate-term relief of CDH, when compared with a control toothpaste (Cocoricó®).

Materials And Methods: Eight patients were enrolled in this clinical study.

Occurrence of anti-Toxoplasma gondii antibodies and parasite DNA in backyard chicken breeding in Northeast, Brazil.

The aim of the present study was to investigate the occurrence of anti-Toxoplasma gondii antibodies and parasite DNA in backyard chickens bred in the metropolitan area of Recife, Brazil. In total, 212 serum samples were collected from 16 properties, and 12 backyard chickens were collected in the six sanitary districts of Recife. An indirect immunofluorescence assay (IFA) was used to investigate the occurrence of anti-Toxoplasma gondii antibodies.

Cardiovascular Surgery Residency Program: Training Coronary Anastomosis Using the Arroyo Simulator and UNIFESP Models.

Objective: Engage the UNIFESP Cardiovascular Surgery residents in coronary anastomosis, assess their skills and certify results, using the Arroyo Anastomosis Simulator and UNIFESP surgical models.

Methods: First to 6th year residents attended a weekly program of technical training in coronary anastomosis, using 4 simulation models: 1. Arroyo simulator; 2.

The social in health: trajectory and contributions of Maria Cecilia Ferro Donnangelo.

This text covers the professional and scientific career of Maria Cecilia Ferro Donnangelo, professor, researcher and influential intellectual in the area of Collective Health. Born in 1940, and killed in a car accident in 1983, she actively participated in the emergence of Collective Health in Brazil and greatly influenced the creation of the sub-areas of Social Science and the Humanities in the health field. Her brief biography, contextualized professional choices and scientific production is hereby presented.

Continuous cultivation of photosynthetic microorganisms: Approaches, applications and future trends.

The possibility of using photosynthetic microorganisms, such as cyanobacteria and microalgae, for converting light and carbon dioxide into valuable biochemical products has raised the need for new cost-efficient processes ensuring a constant product quality. Food, feed, biofuels, cosmetics and pharmaceutics are among the sectors that can profit from the application of photosynthetic microorganisms. Biomass growth in a photobioreactor is a complex process influenced by multiple parameters, such as photosynthetic light capture and attenuation, nutrient uptake, photobioreactor hydrodynamics and gas-liquid mass transfer.

[Medicine under the lens of history: theoretical and methodological reflections].

The need for studies in the field of health to be based on a historical perspective has opened up new horizons for the analysis of the conditions for the creation of a body of knowledge aimed at explaining the role of social elements in determining pathological processes and health practices. The purpose of this paper is to examine how historical science, with its methodological aspects of analysis, has contributed to the physician's practice, especially raising broader critical aspects of the issues related to the field of health care. It is based on dialogues between culture and society molded around a discursive order to act not just as a language, but in its effective implementation within a medical rationale, with attention to the ruptures and continuities of a scientific discourse.

Photodegradation of non-ionic surfactant with different ethoxy groups in aqueous effluents by the photo-Fenton process.

The photo-Fenton process was applied to degrade non-ionic surfactants with different numbers of ethoxy groups, seven (E7), ten (E10) and twenty-three (E23). The effects of H2O2 concentration, Fe(II) concentration and number of ethoxy groups on the mineralization of surfactants were investigated. The response surface methodology (RSM) was applied to determine optimal concentrations of Fenton's reagents for each surfactant.

[Institutionalization of Public Health Care in Sao Paulo between 1930 and 1940].

The aim of the study was to interpret and understand the institutionalization of public health care in the state of Sao Paulo over the years 1930-1940, based on the history of medical specialties. The methodology involved analysis of new sources of documents, which were compared with the existing literature, thereby leading to identification of new indices relating to the issue of eugenics and the presence of physicians' religious beliefs as a social movement. As physicians became public health experts, they proposed a project to elevate the Brazilian race, by merging the hygienist discourse with sanitary actions.

Application of artificial neural network for modeling of phenol mineralization by photo-Fenton process using a multi-lamp reactor.

An artificial neural network (ANN) was implemented for modeling phenol mineralization in aqueous solution using the photo-Fenton process. The experiments were conducted in a photochemical multi-lamp reactor equipped with twelve fluorescent black light lamps (40 W each) irradiating UV light. A three-layer neural network was optimized in order to model the behavior of the process.

[Historical aspects of the institutionalization of adolescent healthcare in the state of São Paulo, 1970-1990].

The article explores historical aspects of integral healthcare for adolescents in the state of São Paulo, particularly in regard to the implementation of pioneering services and programs. Against the backdrop of Brazil's social and political context during this period, it contextualizes the challenges, clashes, and difficulties that arose within the institutions involved in developing this field, from the perspectives of clinical medicine and of collective health. Grounded on documental material, the study re-examines the construction of groups of expertise and of the field of adolescent health care as part of the dialectical interplay between the construction of a new area of medical practice based on clinical work and a field of knowledge and practices in collective health based on integral health care of an interdisciplinary, inter-sectoral nature.

Absence of arteriosclerosis in intramyocardial coronary arteries: a mystery to be solved?

Several studies show that portions of intramyocardial coronary arteries are spared of arteriosclerosis, involving morphological, embryological, biochemical and pathophysiological aspects. Endothelial function is significantly affected in the segment of transition, as estimated by the vasoactive response to Ach. These findings suggest that myocardial bridge can provide protection against arteriosclerosis by counteracting the negative effects of endothelial dysfunction.