Effect of 70 Gy tumor therapeutic radiation applied intermittently or directly on microcosm biofilm composition and dental hard tissues and its potential to cause dental caries.

Objectives: This study compared total (70 Gy, one session) and intermittent (35 sessions of 2 Gy) tumor radiation protocols on tooth morphology (n=5) using Scanning Electron Microscopy-Energy Dispersive X-ray (SEM-EDX) and on microcosm biofilm microbiota (n=12) through colony-forming unit (CFU) counts for Candida spp., total microorganisms, Streptococcus mutans, and total lactobacillus. It also assessed "radiation caries" development via Transverse Microradiography (TMR, n=12).

Pain during Removal of Carious Lesions in Children: A Randomized Controlled Clinical Trial.

The aim of the present study was to assess pain and the need for anesthesia during chemomechanical caries removal with Papacarie gel and the traditional method (low-speed bur) in pediatric patients. A randomized, controlled, clinical trial with a "split-mouth" design was carried out involving 20 children (10 girls and 10 boys) aged four to seven years. Forty primary teeth (two per child) were randomly allocated to either Group 1 (G1: chemomechanical caries removal with Papacarie gel) or Group 2 (G2: removal of carious dentin with low-speed bur).

Inflammatory events during murine squamous cell carcinoma development.

Background: Squamous cell carcinoma (SCC) is one of the most common human cancers worldwide. In SCC, tumour development is accompanied by an immune response that leads to massive tumour infiltration by inflammatory cells, and consequently, local and systemic production of cytokines, chemokines and other mediators. Studies in both humans and animal models indicate that imbalances in these inflammatory mediators are associated with cancer development.