Ring Fracture of Brazilian Aortic Valve Bioprostheses Using Non-Compliant High-Pressure Transcatheter Balloon, an Ex Vivo Test.

Introduction: Aortic valve bioprostheses ring fracture in valve-in-valve procedures has shown low complication rates and presents as an option in the treatment of patients at high risk for conventional surgery, avoiding high transvalvular gradients, which are associated with increased mortality. Some prostheses available in the market cannot be fractured. In an ex vivo test, the possibility of ring fracture of aortic valve bioprostheses produced in Brazil when submitted to radial force application using a high-pressure non-compliant balloon was evaluated.

Immunohistochemical Expression of Melatonin Receptor MT1 and Glucose Transporter GLUT1 in Human Breast Cancer.

Background: Breast cancer is a heterogeneous disease and is the leading cause of cancer-related deaths among women. Even after diagnosis, the prognosis cannot be concluded since patients can develop resistance to therapy, which favors tumor growth, invasion and metastasis. In recent years, research has focused on identifying significant markers that can be used to determine the prognosis.

Melatonin restrains angiogenic factors in triple-negative breast cancer by targeting miR-152-3p: In vivo and in vitro studies.

Aims: Breast cancer represents the second most prevalent tumor-related cause of death among women. Although studies have already been published regarding the association between breast tumors and miRNAs, this field remains unclear. MicroRNAs (miRNAs) are defined as non-coding RNA molecules, and are known to be involved in cell pathways through the regulation of gene expression.

Cardiovascular Surgery Residency Program: Training Coronary Anastomosis Using the Arroyo Simulator and UNIFESP Models.

Objective: Engage the UNIFESP Cardiovascular Surgery residents in coronary anastomosis, assess their skills and certify results, using the Arroyo Anastomosis Simulator and UNIFESP surgical models.

Methods: First to 6th year residents attended a weekly program of technical training in coronary anastomosis, using 4 simulation models: 1. Arroyo simulator; 2.

Photodegradation of non-ionic surfactant with different ethoxy groups in aqueous effluents by the photo-Fenton process.

The photo-Fenton process was applied to degrade non-ionic surfactants with different numbers of ethoxy groups, seven (E7), ten (E10) and twenty-three (E23). The effects of H2O2 concentration, Fe(II) concentration and number of ethoxy groups on the mineralization of surfactants were investigated. The response surface methodology (RSM) was applied to determine optimal concentrations of Fenton's reagents for each surfactant.

Application of artificial neural network for modeling of phenol mineralization by photo-Fenton process using a multi-lamp reactor.

An artificial neural network (ANN) was implemented for modeling phenol mineralization in aqueous solution using the photo-Fenton process. The experiments were conducted in a photochemical multi-lamp reactor equipped with twelve fluorescent black light lamps (40 W each) irradiating UV light. A three-layer neural network was optimized in order to model the behavior of the process.

Absence of arteriosclerosis in intramyocardial coronary arteries: a mystery to be solved?

Several studies show that portions of intramyocardial coronary arteries are spared of arteriosclerosis, involving morphological, embryological, biochemical and pathophysiological aspects. Endothelial function is significantly affected in the segment of transition, as estimated by the vasoactive response to Ach. These findings suggest that myocardial bridge can provide protection against arteriosclerosis by counteracting the negative effects of endothelial dysfunction.

[Adult cardiopulmonary bypass in the twentieth century: science, art or empiricism?].

The aim of the present review is to highlight some less discussed aspects of the cardiopulmonary bypass (CPB), taking into consideration the physiology, physiopathology, and some new technologies of perfusion. Thus, some points, to a certain extent philosophical, have motivated this revision: a) To preserve and update the surgeon knowledge regarding CPB, even to keep his/her pedagogical leadership on his/her surgical team; b) To question if elderly and diabetic patients, as a result of their individual characteristics deserve more appropriate protocols similar to those adopted for children; c) One third aspect would be the questioning of the systemic inflammatory reaction caused by the blood exposure to CPB non-endothelized circuit surface, in face of the increasing importance of blood contact with the surgical wound; d) In relation to the treatment of the vasoplegic syndrome, methylene blue continues being the best therapeutical option, even so, many times are not efficient on account of a highly probable existence of a "therapeutical window" based on the guanylate cyclase dynamics of action (saturation and synthesis "de novo") and; finally, e) The reason of the title, highlighting that based on its current patterns, would the CPB be an outcome of empiricism, art, or science? The bottom line of this article carries the certainty of that as much as the empiricism, art, and science are highly related to CPB.

Application of the photo-Fenton process to the treatment of wastewaters contaminated with diesel.

The application of the photo-Fenton process for the treatment of wastewaters contaminated with diesel oil was investigated. This particular process has been widely studied for the photochemical degradation of highly toxic organic pollutants. Experiments were performed according to a factorial experimental design at two levels and two variables: H(2)O(2) concentration (5-200 mM) and Fe(2+) concentration (0.