Publications by authors named "Andre Gustavo Pires Sousa"
Article Synopsis
- - GPIHBP1 is crucial for the function of lipoprotein lipase (LPL), and mutations in the GPIHBP1 gene can cause serious health issues like hypertriglyceridemia and pancreatitis.
- - This study identifies a new homozygous mutation in the GPIHBP1 gene found in twelve patients from Brazil, affecting how the gene processes and leading to significant health implications.
- - The mutation, located in a critical splicing site, results in severe hypertriglyceridemia and low HDL levels in patients, with a notable percentage having a history of acute pancreatitis, indicating a potential founder effect in this population.
Impaired heart rate variability, Valsalva and 30:15 ratio indexes are associated with reduced submaximal exercise capacity in subjects with diabetes mellitus.
Diabetes Res Clin Pract
September 2019
Aims: To assess cardiac autonomic control and its association with submaximal exercise measured using the 6-minute walk test (6MWT) in subjects with type-2 diabetes mellitus (DM2).
Methods: Cardiac autonomic control was assessed using Ewing's tests and heart rate variability (HRV) in DM2 volunteers (DG, n = 22) and sex-, age- and body mass index-matched non-diabetic controls (CG, n = 22) before, during and after 6MWT.
Results: Before the 6MWT, DG presented lower HRV represented by reduced SDNN [median 28.
Background: The association of type 2 Diabetes Mellitus (DM2) with depressive symptoms may affect the quality of life of older adults and increase their risk of morbidity and deterioration in functional activities. This study aimed to investigate the variables related to depressive symptoms in older adult patients with DM2.
Methods: This cross-sectional, descriptive, analytical study included 102 older adult patients with DM2, treated in northeastern Brazil.