A clinical and histological comparison of two different bone augmentation materials in the atrophic pre-maxilla.

This case study was conducted to compare the regenerative potential of bovine xenograft versus demineralized freeze-dried bone allograft in a thermoplastic biologic carrier in regards to achieving regeneration of bone width as well as potential bone height. The objective for the patient was to gain adequate bone volume for the placement of dental implants using the two different forms of graft material--one with a slow resorption time and the other in a gelatin matrix to provide dimensional stability. The results of this case report are inconclusive to demonstrate the superiority of one of the two graft materials over the other in reconstructing a severely atrophied maxilla.

Effect of nitisinone (NTBC) treatment on the clinical course of hepatorenal tyrosinemia in Québec.

Background: Hepatorenal tyrosinemia (HT1, fumarylacetoacetate hydrolase deficiency, MIM 276700) can cause severe hepatic, renal and peripheral nerve damage. In Québec, HT1 is frequent and neonatal HT1 screening is practiced. Nitisinone (NTBC, Orfadin ®) inhibits tyrosine degradation prior to the formation of toxic metabolites like succinylacetone and has been offered to HT1 patients in Québec since 1994.

Newborn screening for hepatorenal tyrosinemia by tandem mass spectrometry: analysis of succinylacetone extracted from dried blood spots.

Objectives: To develop a method for the determination of succinylacetone (SA) in dried blood spots (DBS) using tandem mass spectrometry (MS/MS).

Methods: SA was extracted from DBS with an acetonitrile and water solution (80:20 by volume) containing formic acid and hydrazine hydrate (both at 0.1% by volume), and analyzed by MS/MS with a total run time per sample under 2 min.