PP2A phosphatase regulates cell-type specific cytoskeletal organization to drive dendrite diversity.

Uncovering molecular mechanisms regulating dendritic diversification is essential to understanding the formation and modulation of functional neural circuitry. Transcription factors play critical roles in promoting dendritic diversity and here, we identify PP2A phosphatase function as a downstream effector of Cut-mediated transcriptional regulation of dendrite development. Mutant analyses of the PP2A catalytic subunit () or the scaffolding subunit ( reveal cell-type specific regulatory effects with the PP2A complex required to promote dendritic growth and branching in Class IV (CIV) multidendritic (md) neurons, whereas in Class I (CI) md neurons, PP2A functions in restricting dendritic arborization.