ASIA syndrome: Adverse reaction or autoimmunity?

Introduction: Adjuvant-Induced Autoimmune / Auto-inflammatory Syndrome (ASIA) is an immune-mediated condition by the exposure of material previously considered inert, such as silicone, aluminum salts, mineral oils, hyaluronic acid and metallic implants. In addition to a genetic component, there is a risk of development of an undifferentiated connective tissue disease, which varies clinically and laboratorially depending on the adjuvant material used.

Patients And Methods: This paper addresses two cases reported, in caucasian subjects, born and residents in Madeira Island, Portugal.

Benign metastasizing leiomyoma - a case of benign metastasis.

Leiomyomas are benign tumours of smooth muscle cells that most often affect the female genital tract, but their metastasis to extra-uterine locations represent rare, yet misunderstood phenomena. The authors present a clinical case of a 42-year-old woman, who underwent a hysterectomy 15 years ago due to myomas, admitted with multiple pulmonary nodules and abdominal mass, diagnosed by imaging tests, in the context of haemoptysis. The anatomopathological exams of the pulmonary and abdominal lesions were compatible with the diagnosis of benign metastatic leiomyoma.

Cutaneous manifestations associated with SARS-CoV-2: an emerging topic in a pandemic era.

A 70-year-old man was admitted to our COVID-19 ward with thoracalgia, productive mucus cough, fatigue and erythematous-violaceous macules on the inner side of feet and interdigital regions. The patient was started on oxygen and dexamethasone. On the day of discharge, he maintained the skin changes despite the resolution of COVID-19 symptoms.

Heart Dissemination: A Clinical Case of Melanoma.

. Primitive malignant heart tumours are rare, specific cases. The presence of cardiac metastases, often in the pericardium, besides indicating disseminated oncological disease, represents a diagnostic challenge since they tend to be asymptomatic.

Acute Iatrogenic Agranulocytosis: A Rare and Dire Case of an Adverse Drug Reaction to Be Aware.

Background: Iatrogenic agranulocytosis (IA), by nonchemotherapeutic drugs, is a rare adverse event, resulting in a neutrophil count under 0.5 × 10 cells/L with fever or other suggestive signs of infection.

Methods: This paper discusses the possible mechanisms responsible for agranulocytosis induced by nonchemotherapeutic drugs.

Monte Carlo Simulations of the GE Signa PET/MR for Different Radioisotopes.

Unlabelled: NEMA characterization of PET systems is generally based on F because it is the most relevant radioisotope for the clinical use of PET. F has a half-life of 109.7 min and decays into stable O via β+ emission with a probability of over 96% and a maximum positron energy of 0.