Publications by authors named "Andre Carramenha de Goes Hirano"
Article Synopsis
- - Sickle cell disease varies in its genetic presentation and primarily impacts populations with ancestry from sub-Saharan Africa, parts of the Western Hemisphere, Saudi Arabia, and India, due to the protective effects against malaria for carriers of certain genes.
- - While newborn screening for sickle cell disease is improving early diagnosis, many patients lack access to proper treatment, follow-up care, and genetic counseling, leading to increased health risks.
- - The case of a 36-year-old man highlights the severity of sickle cell complications, as he suffered a fatal sickling crisis, underscoring the potential for severe outcomes even in patients with the milder HbSC form of the disease.
In 2005, the combined pulmonary fibrosis and emphysema (CPFE) was first defined as a distinct entity, which comprised centrilobular or paraseptal emphysema in the upper pulmonary lobes, and fibrosis in the lower lobes accompanied by reduced diffused capacity of the lungs for carbon monoxide (DLCO). Recently, the fibrosis associated with the connective tissue disease was also included in the diagnosis of CPFE, although the exposure to tobacco, coal, welding, agrochemical compounds, and tire manufacturing are the most frequent causative agents. This entity characteristically presents reduced DLCO with preserved lung volumes and severe pulmonary hypertension, which is not observed in emphysema and fibrosis alone.
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