Advanced renal cell carcinoma management: the Latin American Cooperative Oncology Group (LACOG) and the Latin American Renal Cancer Group (LARCG) consensus update.

Purpose: Renal cell carcinoma is an aggressive disease with a high mortality rate. Management has drastically changed with the new era of immunotherapy, and novel strategies are being developed; however, identifying systemic treatments is still challenging. This paper presents an update of the expert panel consensus from the Latin American Cooperative Oncology Group and the Latin American Renal Cancer Group on advanced renal cell carcinoma management in Brazil.

Efficacy of immune checkpoint inhibitors combinations as first-line systemic treatment in patients with advanced urothelial carcinoma: A systematic review and network meta-analysis.

Background: Combinations of immune checkpoint inhibitors (ICI) with platinum-based chemotherapy (PlatinumCT) or with another ICI in the first-line setting for patients with metastatic urothelial carcinoma (mUC) have mixed results.

Methods: Records were searched electronically from January 2019 to January 2024. A meta-analysis was performed to evaluate OS, progression-free survival (PFS), and overall response rate (ORR).

Effects of Resistance Training on Oxidative Stress Markers and Muscle Damage in Spinal Cord Injured Rats.

Background: Spinal cord injury (SCI) is a condition that affects the central nervous system, is characterized by motor and sensory impairments, and impacts individuals' lives. The objective of this study was to evaluate the effects of resistance training on oxidative stress and muscle damage in spinal cord injured rats.

Methodology: Forty Wistar rats were selected and divided equally into five groups: Healthy Control (CON), Sham (SHAM) SCI Untrained group (SCI-U), SCI Trained group (SCI- T), SCI Active Trained group (SCI- AT).

Effects of Ibuprofen Intake in Muscle Damage, Body Temperature and Muscle Power in Paralympic Powerlifting Athletes.

The aim of this study is to evaluate the effect of ingesting ibuprofen on post-workout recovery of muscle damage, body temperature and muscle power indicators in Paralympic powerlifting athletes. The study was carried out with eight Paralympic powerlifting athletes (aged 27.0 ± 5.

Dyslipidemia prevalence in adolescents in public schools.

Objective: To evaluate the prevalence of dyslipidemia in adolescents enrolled in the state public education system of the city of Montes Claros, state of Minas Gerais, and compare to a Brazilian population-based study.

Method: This is an epidemiological, cross-sectional, and analytical study with a population of 77,833 students from 63 schools, representing four geographic areas of the city. After a sample calculation, information on 635 adolescents from 10 to 16 years of age was assessed and blood collection was conducted for the analysis of biochemical parameters of total cholesterol, triglycerides, LDL-c, and HDL-c.

Correction: Are wearable heart rate measurements accurate to estimate aerobic energy cost during low-intensity resistance exercise?

[This corrects the article DOI: 10.1371/journal.pone.

Extract Has an Effect on Muscle Damage and Lipid Peroxidation in Rats Submitted to High Intensity Strength Exercise?

Many species of the genus have been used for anti-inflammatory, antiproliferative, antidiabetic, and antitumor purposes. The objective was to evaluate the effect of a hydroethanolic extract (HEE) from the inner bark of (Euphorbiaceae) on muscle damage and oxidative stress in rats after high intensity exercise. The animals were divided into four groups: (i) the sedentary group (SV; = 7), (ii) the exercise vehicle group (EV, = 7), (iii) the sedentary group HEE (SHG; = 7) composed of sedentary animals and treated with the hydroethanolic extract of (200 mg/kg, v.

Are wearable heart rate measurements accurate to estimate aerobic energy cost during low-intensity resistance exercise?

The aim of the present study was to assess the accuracy of heart rate to estimate energy cost during eight resistance exercises performed at low intensities: half squat, 45° inclined leg press, leg extension, horizontal bench press, 45° inclined bench press, lat pull down, triceps extension and biceps curl. 56 males (27.5 ± 4.

Oxygen Uptake On-Kinetics during Low-Intensity Resistance Exercise: Effect of Exercise Mode and Load.

Oxygen uptake (VO) kinetics has been analyzed through mathematical modeling of constant work-rate exercise, however, the exponential nature of the VO response in resistance exercise is currently unknown. The present work assessed the VO on-kinetics during two different sub maximal intensities in the inclined bench press and in the seated leg extension exercise. Twelve males (age: 27.

Treatment of Atypical Bifid Mandibular Condyle Associated with Ankylosis of the Temporomandibular Joint.

Introduction: The bifid mandibular condyle (BMC) is an unusual temporomandibular joint (TMJ) disorder with controversial etiology. The association of this entity with ankylosis is rare.

Objective: The objective of the present study is to report a case of BMC with associated TMJ ankylosis in a patient with no history of trauma and/or infection.

Effects of resistance training on the physical condition of people with multiple sclerosis.

Background: This study aimed to evaluate the effect of resistance training on the functional capacity of people with multiple sclerosis. Two groups were defined intentionally and divided based on the Expanded Disability Status Scale (EDSS): an experimental group (EG) consisting of 11 individuals, 18.2% with an EDSS Score of 0-3.

A randomized trial of the effects of an aquatic exercise program on depression, anxiety levels, and functional capacity of people who suffered an ischemic stroke.

Background: Aquatic exercise programs are used in rehabilitation and might help to reduce disability after stroke. This was a randomized intervention trial to assess the influence of an aquatic exercise program on people suffering from depression and anxiety after ischemic stroke.

Methods: Participants were randomized to an experimental group (EG) composed of 19 individuals (51.

Influence of aquatic exercises in physical condition in patients with multiple sclerosis.

Background: Multiple sclerosis (MS) is a disabling chronic disease of the nervous system in which the myelin system of the central nervous system is deteriorated. This study aimed to evaluate the effectiveness of an aquatic exercise program on the physical condition of patients suffering from multiple sclerosis.

Methods: The study included 26 participants divided into two groups: an experimental group (EG) with 13 individuals and a control group (CG) also with 13 individuals.

An analysis of the quality indicators of the organ donation process in São Paulo, Brazil.

Background: Few studies have investigated whether quality initiatives in the process of organ donation yield better results of the organ donation process.

Objective: To analyze whether the indicators of the organ donation process in Brazilian hospitals meet the standards established by the Organ Donation European Quality System (ODEQUS).

Design: We evaluated the quality of the organ donation in a selected group of Brazilian hospitals served by the Nucleus of Organ Procurement (NOP) using standards of the ODEQUS.

Cardiorespiratory fitness and body composition in postmenopausal women.

The object of the study was to analyze the relationship between aerobic fitness and body composition in postmenopausal women. We hypothesized that postmenopausal women that had higher adiposity had lower cardiorespiratory capacity, regardless of the characteristics of menopause. The sample included 208 women (57.

Nutritional Status Associated with Metabolic Syndrome in Middle-School Children in the City of Montes Claros - MG, Brazil.

The aim of this study was to investigate the association between nutritional status and prevalence of metabolic syndrome (MS) in middle-school students in the city of Montes Claros - MG. The sample consisted of 382 students, aged 10-16 years. Nutritional status was evaluated using the Body Mass Index (BMI).

Relationship between Depression and Strength Training in Survivors of the Ischemic Stroke.

The Cerebral Vascular Accident is responsible for a significant increase in the mortality rate in individuals who have suffered this condition, regardless of the level of subsequent disability. This study aimed to analyze the influence of a strength training program on indicators of depression in survivors of the ischemic stroke. The study sample included subjects from both genders who were divided into two groups: an experimental group (EG) consisting of 11 subjects aged 51.

Effects of body fat and dominant somatotype on explosive strength and aerobic capacity trainability in prepubescent children.

The purpose of this study was to analyze the influence of body fat and somatotype on explosive strength and aerobic capacity trainability in the prepubertal growth spurt, marked by rapid changes in body size, shape, and composition, all of which are sexually dimorphic. One hundred twenty-five healthy children (58 boys, 67 girls), aged 10-11 years (10.8 ± 0.

[Impact of an exercise program in adiposity and muscular condition of postmenopausal women].

Purpose: To evaluate the effect of an exercise program on fat mass (FM), visceral fat area (VFA), skeletal muscle mass (SMM) and skeletal muscle mass index (SMMI) of post-menopausal women.

Methods: A sample of 169 women (56.8±6.

The influence of the level of physical activity and human development in the quality of life in survivors of stroke.

Background: The association between physical activity and quality of life in stroke survivors has not been analyzed within a framework related to the human development index. This study aimed to identify differences in physical activity level and in the quality of life of stroke survivors in two cities differing in economic aspects of the human development index.

Methods: Two groups of subjects who had suffered a stroke at least a year prior to testing and showed hemiplegia or hemiparesis were studied: a group from Belo Horizonte (BH) with 48 people (51.

MamMiBase: a mitochondrial genome database for mammalian phylogenetic studies.

Unlabelled: MamMiBase, the mammalian mitochondrial genome database, is a relational database of complete mitochondrial genome sequences of mammalian species. The database is useful for phylogenetic analysis, since it allows a ready retrieval of nucleotide and aminoacid individual alignments, in three different formats (NEXUS for PAUP program, for MEGA program and for PHYLIP program) of the 13 protein coding mitochondrial genes. The user may download the sequences that are useful for him/her based on their parameters values, such as sequence length, p-distances, base content, transition transversion ratio, gamma, which are also given by MamMiBase.