Covalently Immobilizable Tris(Pyridino)-Crown Ether for Separation of Amines Based on Their Degree of Substitution.

A great number of biologically active compounds contain at least one amine function. Appropriate selectivity can only be accomplished in a few cases upon the substitution of these groups, thus functionalization of amines generally results in a mixture of them. The separation of these derivatives with very similar characteristics can only be performed on a preparative scale or by applying pre-optimized HPLC methods.

Resolution of 1-n-butyl-3-methyl-3-phospholene 1-oxide with TADDOL derivatives and calcium salts of O,O'-Dibenzoyl-(2R,3R)- or O,O'-di-p-toluoyl-(2R,3R)-tartaric acid.

The resolution methods applying (-)-(4R,5R)-4,5-bis(diphenylhydroxymethyl)-2,2-dimethyldioxolane ("TADDOL"), (-)-(2R,3R)-α,α,α',α'-tetraphenyl-1,4-dioxaspiro[4.5]decan-2,3-dimethanol ("spiro-TADDOL"), as well as the acidic and neutral Ca(2+) salts of (-)-O,O'-dibenzoyl- and (-)-O,O'-di-p-toluoyl-(2R,3R)-tartaric acid were extended for the preparation of 1-n-butyl-3-methyl-3-phospholene 1-oxide in optically active form. In one case, the intermediate diastereomeric complex could be identified by single-crystal X-ray analysis.

[Preoperative chemotherapy in the surgical treatment of colorectal liver metastases].

Introduction: The only curative treatment of colorectal liver metastases (CRLM) is surgical resection. Preoperative/neoadjuvant chemotherapy can be used for resectable, for borderline resectable or even for irresectable CRLM patients.

Patients: Data of CRLM patients treated with surgical resection at the Uzsoki Hospital were analysed.

Sensory evaluation and electronic tongue for sensing flavored mineral water taste attributes.

In this article a trained sensory panel evaluated 6 flavored mineral water samples. The samples consisted of 3 different brands, each with 2 flavors (pear-lemon grass and josta berry). The applied sensory method was profile analysis.

Discrimination of mineral waters by electronic tongue, sensory evaluation and chemical analysis.

Mineral, spring and tap water samples of different geographical origins (7 classes) were distinguished by various methods, such as sensory evaluation, electronic tongue measurement, inductively coupled plasma atomic emission spectroscopy and ion chromatography. Samples from the same geographical origin were correctly classified by chemical analysis and electronic tongue (100%), but it was found that only 80% classification rate can be achieved by sensory evaluation. Different water brands (different brand names) from the same geographical origin did not show definite differences, as expected.

[Posterior locked shoulder fracture-dislocation: anatomical resconstruction of reverser Hill-Sachs lession].

The posterior instability of the shoulder only represents 4% of the shoulder instabilities. For the diagnosis, the antero-posterior, transtoracic and axilar radiographic projections are recommended. The inverted Hill-Sachs lesion is a fracture caused by compression of the antero-medial part of the humeral head during the posterior dislocation.

Methods for Improving Image Quality and Reducing Data Load of NIR Hyperspectral Images.

Near Infrared Hyperspectral Imaging (NIRHSI) is an emerging technology platform that integrates conventional imaging and spectroscopy to attain both spatial and spectral information from an object. Two important problems in NIRHSI are those of data load and unserviceable pixels in the NIR sensor. Hyperspectral imaging experiments generate large amounts of data (typically > 50 MB per image), which tend to overwhelm the memory capacity of conventional computer systems.