Publications by authors named "Andranik Mshetsyan"
Article Synopsis
- A study looked at how steroids, like prednisone, help reduce congestion in patients with acute heart failure (AHF).
- Patients taking prednisone showed more improvement in their congestion levels compared to those receiving regular care.
- The results suggest that steroids can help with symptoms related to congestion, but more research is needed to confirm these findings.
Article Synopsis
- * Patients receiving prednisone showed a significant reduction in inflammation as indicated by decreased levels of high-sensitivity C-reactive protein (hsCRP) and a notably lower risk of heart failure worsening, readmissions, or death over 90 days compared to the usual care group.
- * While burst steroid therapy improved outcomes like quality of life and reduced heart failure risks, it was associated with more adverse events like hyperglycemia, indicating a need for larger studies to confirm these findings and further assess safety
Aims: Inflammation has emerged as a potential key pathophysiological mechanism in heart failure (HF) in general and acute HF (AHF) specifically, with inflammatory biomarkers shown to be highly predictive of adverse outcomes in these patients. The CORTAHF study builds on both these data and the fact that steroid burst therapy has been shown to be effective in the treatment of respiratory diseases and COVID-19. Our hypothesis is that in patients with AHF and elevated C-reactive protein (CRP) levels without symptoms or signs of infection, a 7-day course of steroid therapy will lead to reduced inflammation and short-term improvement in quality of life and a reduced risk of worsening HF (WHF) events.
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