Publications by authors named "Andrada L Lazar"
Article Synopsis
- Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, enhancing survival rates for patients with advanced cancers like melanoma and lung cancer by boosting the immune system's response to tumors.
- These therapies target specific proteins (PD1, PD-L1, CTLA-4) that regulate T cell activity, which helps the immune system identify and attack malignant cells.
- However, ICIs can cause serious cardiac side effects, such as myocarditis, leading to significant health risks, prompting a need for ongoing research and understanding of these immune-related adverse events.
Subacute cutaneous lupus erythematosus: A facultative paraneoplastic dermatosis.
Clin Dermatol
December 2022
Subacute cutaneous lupus erythematosus (SCLE) is a photosensitive dermatosis characterized by a nonscarring papulosquamous eruption and specific antibodies in the patient's serum. Genetic and environmental factors represent the leading causes of SCLE; however, several case reports in the literature link SCLE to various types of cancer. This review assesses the association between SCLE and neoplastic disorders.
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- - The COVID-19 pandemic has caused over 3.4 million deaths globally and is linked to the SARS-CoV-2 virus, affecting not just the lungs but also the cardiovascular system.
- - The disease can vary from mild symptoms to severe respiratory failure due to lung damage, which is influenced by both acute respiratory distress syndrome and blood vessel complications.
- - Recent studies indicate COVID-19 is primarily an endothelial disease, leading to inflammation, oxidative stress, and clotting issues, emphasizing the need for targeted therapies focusing on endothelial dysfunction.
Metabolic syndrome (MetS) represents a cluster of disorders that increase the risk of a plethora of conditions, in particular type two diabetes, cardiovascular diseases, and certain types of cancers. MetS is a complex entity characterized by a chronic inflammatory state that implies dysregulations of adipokins and proinflammatory cytokins together with hormonal and growth factors imbalances. Of great interest is the implication of microRNA (miRNA, miR), non-coding RNA, in cancer genesis, progression, and metastasis.
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