Methadone Destabilizes Cardiac Repolarization During Sleep.

Methadone, a widely prescribed medication for chronic pain and opioid addiction, is associated with respiratory depression and increased predisposition for torsades de pointes, a potentially fatal arrhythmia. Most methadone-related deaths occur during sleep. The objective of this study was to determine whether methadone's arrhythmogenic effects increase during sleep, with a focus on cardiac repolarization instability using QT variability index (QTVI), a measure shown to predict arrhythmias and mortality.

The Effects of the Yes You Can! Curriculum on the Sexual Knowledge and Intent of Middle School Students.

Background: The purpose of the study was to examine the effects of the "Yes You Can!" (YYC) curriculum on sexual knowledge and behavioral intent of program participants.

Methods: Participants included students ages 10-14 from schools in a northeast US urban area. Yes You Can! program lessons were designed to support healthy relationships.

Predicting successful long-term weight loss from short-term weight-loss outcomes: new insights from a dynamic energy balance model (the POUNDS Lost study).

Background: Currently, early weight-loss predictions of long-term weight-loss success rely on fixed percent-weight-loss thresholds.

Objective: The objective was to develop thresholds during the first 3 mo of intervention that include the influence of age, sex, baseline weight, percent weight loss, and deviations from expected weight to predict whether a participant is likely to lose 5% or more body weight by year 1.

Design: Data consisting of month 1, 2, 3, and 12 treatment weights were obtained from the 2-y Preventing Obesity Using Novel Dietary Strategies (POUNDS Lost) intervention.

Brief report: parental child-directed speech as a predictor of receptive language in children with autism symptomatology.

Facilitative linguistic input directly connected to children's interest and focus of attention has become a recommended component of interventions for young children with autism spectrum disorder (ASD). This longitudinal correlational study used two assessment time points and examined the association between parental undemanding topic-continuing talk related to the child's attentional focus (i.e.