Progression of Nigrostriatal Denervation in Cerebellar Multiple System Atrophy: A Prospective Study.

Objectives: Nigrostriatal dopaminergic denervation (NSDD) remains poorly characterized in cerebellar multiple system atrophy (MSA-C). We aimed to study NSDD progression in MSA-C and evaluate the capacity for [123I]-FP-CIT-SPECT and parkinsonism to differentiate MSA-C from idiopathic late-onset cerebellar ataxia (ILOCA).

Methods: We included 85 patients successively referred for sporadic late-onset cerebellar ataxia (SLOCA).