Publications by authors named "Andhavaram Ramaraju"
Article Synopsis
- * The ST2/IL-33 pathway promotes immune tolerance by expanding regulatory T cells but also triggers proinflammatory cytokine production for immune defense and tissue repair.
- * Researchers developed improved ST2 inhibitors that effectively reduced ST2 upregulation and IL-1β release in human mast cells, suggesting potential for treating diseases mediated by mast cells.
Mutations in RNA splicing factor genes including , , and have been reported to contribute to development of myeloid neoplasms including myelodysplastic syndrome (MDS) and secondary acute myeloid leukemia (sAML). Chemical tools targeting cells carrying these mutant genes remain limited and underdeveloped. Among the four proteins, mutant U2AF1 (U2AF1) acquires an altered 3' splice site selection preference and co-operates with the wild-type U2AF1 (U2AF1) to change various gene isoform patterns to support MDS cells survival and proliferation.
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- Microsomal prostaglandin E synthase-1 (mPGES-1) is an enzyme that produces prostaglandin E2 (PGE) during inflammation, making it a targetable pathway for reducing inflammation without the cardiovascular risks linked to long-term COX inhibition.
- The study focuses on thiazole-based mPGES-1 inhibitors that showed effective suppression of PGE production in both human and mouse cell lines, highlighting their potential therapeutic benefits.
- Further evaluations in an inflammation model revealed that one compound significantly reduced proinflammatory markers in the hippocampus, suggesting it could be beneficial in treating neuroinflammatory conditions like epilepsy and stroke, although additional optimization is needed.
A novel chemoselective [3 + 2] annulation reaction of easily accessible ketoxime acetate with 2-aryl-3-ethoxycarbonyl pyrroline-4,5-dione has been developed for the synthesis of unknown pyrrolo[2,3-]pyrrole frameworks. This method involves copper-mediated N-O bond cleavage followed by the formation of carbon-carbon and carbon-nitrogen bonds. This operationally simple protocol provides broader functional group compatibility and good yields.
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- A copper-mediated domino condensation reaction combines oxime acetates with ninhydrin to create pyrrolo[2,1-a]isoindolediones through new carbon-carbon and carbon-nitrogen bond formations.
- The reaction allows for a wide variety of oxime acetates to be used, resulting in high yields of the desired products.
- The proposed mechanism involves the formation of an iminium radical through the cleavage of the N-O bond, which then reacts with ninhydrin followed by a rearrangement process.
A method for the construction of pyrroles bearing a 2-keto or formyl group through the intramolecular oxidative aza-annulation of enynyl azides is reported for the first time. It involves a sequential carbon-nitrogen/carbon-oxygen bond formations, and the combination of AuCl with AgSbF was identified as a suitable reagent system to promote the present reaction. The required enynyl azides are readily prepared from Morita-Baylis-Hillman (MBH) acetates of acetylenic aldehydes.
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