Measuring attention to reward as an individual trait: the value-driven attention questionnaire (VDAQ).

Reward history is a powerful determinant of what we pay attention to. This influence of reward on attention varies substantially across individuals, being related to a variety of personality variables and clinical conditions. Currently, the ability to measure and quantify attention-to-reward is restricted to the use of psychophysical laboratory tasks, which limits research into the construct in a variety of ways.

A comparison of impulse response modification techniques for time reversal with application to crack detection.

Time reversal (TR) focusing used for nonlinear detection of cracks relies on the ability of the TR process to provide spatially localized, high-amplitude excitation. The high amplitude improves the ability to detect nonlinear features that are a signature of the motion of closed cracks. It follows that a higher peak focal amplitude than what can be generated with the traditional TR process will improve the detection capability.

Pharmacokinetic and Pharmacodynamic Analysis of Alfaxalone Administered as a Bolus Intravenous Injection of Phaxan in a Phase 1 Randomized Trial.

Background: Previous formulations of alfaxalone have shown it to be a fast-acting intravenous anesthetic with high therapeutic index. Alfaxalone has been reformulated for human use as Phaxan, an aqueous solution of 10 mg/mL of alfaxalone and 13% betadex. This study assessed the pharmacokinetic (PK) and pharmacodynamic (PD) characteristics of alfaxalone given as a bolus intravenous injection of this formulation to human male volunteers.

Elucidation of the Structure and Vibrational Spectroscopy of Synthetic Metaschoepite and Its Dehydration Product.

We confirm that synthetic uranyl hydroxide hydrate metaschoepite [(UO)2O(OH)]·5HO is unstable against dehydration under dry conditions, and we present a structural and vibrational spectroscopic study of synthetic metaschoepite and its ambient temperature dehydration product. Complementary structural (X-ray diffraction and neutron diffraction) and vibrational spectroscopic techniques (Raman spectroscopy, infrared spectroscopy, and inelastic neutron scattering) are used to probe different components of these species. Analysis of the dehydration product suggests that it contains both pentagonally coordinated and hexagonally coordinated uranyl ions, necessitating that some uranyl ions undergo a coordination change during the dehydration of pentagonally coordinated metaschoepite.

Pharmacokinetic-pharmacodynamic population modelling in paediatric anaesthesia and its clinical translation.

Purpose Of Review: Pharmacokinetic-pharmacodynamic (PKPD) population modelling has advanced adult anaesthesia. Current literature was reviewed to discern use of this analytic technique for benefit in the perioperative management of children.

Recent Findings: Variability in drug response, selection of a dose that achieves a desired target concentration and optimizing sampling protocols for further studies are all facets of paediatric anaesthesia that have benefitted from modelling approaches.

Advances in Auto-Segmentation.

Manual image segmentation is a time-consuming task routinely performed in radiotherapy to identify each patient's targets and anatomical structures. The efficacy and safety of the radiotherapy plan requires accurate segmentations as these regions of interest are generally used to optimize and assess the quality of the plan. However, reports have shown that this process can be subject to significant inter- and intraobserver variability.

Analgesic efficacy and pharmacokinetics of epidural oxycodone in pain management after gynaecological laparoscopy-A randomised, double blind, active control, double-dummy clinical comparison with intravenous administration.

Aims: Early pain after laparoscopy is often severe. Oxycodone is a feasible analgesic option after laparoscopy, but there are sparse data on epidural administration. The aim was to evaluate the analgesic efficacy and pharmacokinetics of a single dose of epidural oxycodone as a part of multimodal analgesia after gynaecological laparoscopy.

Effect of setup and inter-fraction anatomical changes on the accumulated dose in CT-guided breath-hold intensity modulated proton therapy of liver malignancies.

Purpose: To evaluate the effect of setup uncertainties including uncertainties between different breath holds (BH) and inter-fractional anatomical changes under CT-guided BH with intensity-modulated proton therapy (IMPT) in patients with liver cancer.

Methods And Materials: This retrospective study considered 17 patients with liver tumors who underwent feedback-guided BH (FGBH) IMRT treatment with daily CT-on-rail imaging. Planning CT images were acquired at simulation using FGBH, and FGBH CT-on-rail images were also acquired prior to each treatment.

Psychedelic-Assisted Group Therapy: A Systematic Review.

Contemporary research with classic psychedelic drugs (e.g., lysergic acid diethylamide (LSD) and psilocybin) is indebted to the twentieth-century researchers and clinicians who generated valuable clinical knowledge of these substances through experimentation.

Practicalities of Total Intravenous Anesthesia and Target-controlled Infusion in Children.

Propofol administered in conjunction with an opioid such as remifentanil is used to provide total intravenous anesthesia for children. Drugs can be given as infusion controlled manually by the physician or as automated target-controlled infusion that targets plasma or effect site. Smart pumps programmed with pharmacokinetic parameter estimates administer drugs to a preset plasma concentration.

Long-term Outcome of Globus Pallidus Internus Stimulation for Pisa Syndrome.

Pisa syndrome, defined as dystonia leading to lateral flexion of the spine, is an increasingly recognized complicating factor in the treatment of Parkinson's disease (PD). Symptoms may persist despite medical therapy, or medical therapy may not be tolerated due to adverse effects. Here, we demonstrate the long-term efficacy of deep brain stimulation (DBS) at the globus pallidus internus (GPi) for the treatment of Pisa syndrome.

Threat reduces value-driven but not salience-driven attentional capture.

What we direct our attention to is strongly influenced by both bottom-up and top-down processes. Moreover, the control of attention is biased by prior learning, such that attention is automatically captured by stimuli previously associated with either reward or threat. It is unknown whether value-oriented and threat-oriented mechanisms of selective information processing function independently of one another, or whether they interact with each other in the selection process.

On the automaticity of attentional orienting to threatening stimuli.

Attention is biased toward stimuli that have been associated with aversive outcomes in the past. This bias has previously been interpreted as reflecting automatic orienting toward threat signals. However, in many prior studies, either the threatening stimulus provided valuable predictive information, signaling the possibility of an otherwise unavoidable punishment and thereby allowing participants to brace themselves, or the aversive event could be avoided with fast and accurate task performance.

Treatment of a Patient With Central Pain Sensitization Using Graded Motor Imagery Principles: A Case Report.

Objective: This case report describes the application of graded motor imagery principles to a patient experiencing central sensitization and chronic pain.

Clinical Features: A 46-year-old woman presented with pain in all 4 limbs along with global spinal pain and loss of range of motion. These symptoms initiated after a motor vehicle accident 5 years before and were exacerbated by 2 subsequent motor vehicle accidents.

Hemodynamic and pharmacokinetic analysis of oxymetazoline use during nasal surgery in children.

Objectives/hypothesis: Oxymetazoline is an α-adrenergic agonist that is commonly used as a topical hemostatic agent in the operating room during ear, nose, and throat surgery. There are limited data on oxymetazoline pharmacokinetics in children who undergo general anesthesia. We assessed the hemodynamic effects and systemic absorption of topically applied oxymetazoline in children undergoing various nasal procedures.

Neural correlates of attentional capture by stimuli previously associated with social reward.

Our attention is strongly influenced by reward learning. Stimuli previously associated with monetary reward have been shown to automatically capture attention in both behavioral and neurophysiological studies. Stimuli previously associated with positive social feedback similarly capture attention; however, it is unknown whether such social facilitation of attention relies on similar or dissociable neural systems.

Dissociable Components of Experience-Driven Attention.

What we pay attention to is influenced by current task goals (goal-directed attention) [1, 2], the physical salience of stimuli (stimulus-driven attention) [3-5], and selection history [6-12]. This third construct, which encompasses reward learning, aversive conditioning, and repetitive orienting behavior [12-18], is often characterized as a unitary mechanism of control that can be contrasted with the other two [12-14]. Here, we present evidence that two different learning processes underlie the influence of selection history on attention, with dissociable consequences for orienting behavior.

Circulating heparan sulfate fragments mediate septic cognitive dysfunction.

Septic patients frequently develop cognitive impairment that persists beyond hospital discharge. The impact of sepsis on electrophysiological and molecular determinants of learning is underexplored. We observed that mice that survived sepsis or endotoxemia experienced loss of hippocampal long-term potentiation (LTP), a brain-derived neurotrophic factor-mediated (BDNF-mediated) process responsible for spatial memory formation.

Nonlinearity from stress corrosion cracking as a function of chloride exposure time using the time reversed elastic nonlinearity diagnostic.

The Time Reversed Elastic Nonlinearity Diagnostic (TREND) has a long history of successful nondestructive detection of cracks in solids using nonlinear indicators. Recent research implemented TREND to find stress corrosion cracking (SCC) in the heat-affected zone adjacent to welds in stainless steel. SCC development around welds is likely to occur due to the temperature and chemical exposure of steel canisters housing spent nuclear fuel.

On the relationship between value-driven and stimulus-driven attentional capture.

Reward history, physical salience, and task relevance all influence the degree to which a stimulus competes for attention, reflecting value-driven, stimulus-driven, and goal-contingent attentional capture, respectively. Theories of value-driven attention have likened reward cues to physically salient stimuli, positing that reward cues are preferentially processed in early visual areas as a result of value-modulated plasticity in the visual system. Such theories predict a strong coupling between value-driven and stimulus-driven attentional capture across individuals.

Time reversal acoustics applied to rooms of various reverberation times.

Time Reversal (TR) is a technique that may be used to focus an acoustic signal at a particular point in space. While many variables contribute to the quality of TR focusing of sound in a particular room, the most important have been shown to be the number of sound sources, signal bandwidth, and absorption properties of the medium as noted by Ribay, de Rosny, and Fink [J. Acoust.