Purpose: Patients with Crohn's disease (CD) frequently undergo multiple abdominal operations, which increase the risk of incisional hernia repair (IHR) and associated mesh-related complications. Patients with intra-abdominal fistulizing CD (FCD) may be more susceptible to mesh-related complications than patients with non-fistulizing CD (non-FCD). The primary objective was to evaluate the risk of reoperation due to mesh-related complications after IHR in patients with FCD and non-FCD.
View Article and Find Full Text PDFThe incidence of colon diverticulosis and diverticulitis is increasing. This review summarises the current classification and treatment options. Antibiotic treatment is not indicated for uncomplicated diverticulitis in non-immunosuppressed patients.
View Article and Find Full Text PDFBackground: To study the effect of laparoscopic ileopexy in patients with afferent-loop syndrome (ALS) after restorative proctocolectomy (RP).
Method: Ileopexy has been the treatment of choice in patients with ALS for the last 5 years at our department. All patients who had undergone ileopexy for ALS between January 2019 and August 2023 were identified.
Tardigrade diversity and distribution are enigmatic in most parts of the globe, and only some European countries can boast of a relatively well-studied water bear fauna. However, even these suffer from the lack of genetic data, which would substantiate faunistic data and make biogeographic comparisons easier. Denmark has never been intensively and systematically researched in this regard, thus a citizen science sampling of cryptogams (mosses, liverworts, and lichens) was launched in spring 2023, aiming at a comprehensive biodiversity survey across this insular country.
View Article and Find Full Text PDFAim: Recent evidence challenges the current standard of offering surgery to patients with ileocaecal Crohn's disease (CD) only when they present complications of the disease. The aim of this study was to compare short-term results of patients who underwent primary ileocaecal resection for either inflammatory (luminal disease, earlier in the disease course) or complicated phenotypes, hypothesizing that the latter would be associated with worse postoperative outcomes.
Method: A retrospective, multicentre comparative analysis was performed including patients operated on for primary ileocaecal CD at 12 referral centres.
Background: Surgical management for patients with inflammatory ileocecal Crohn's disease (CD) could be a reasonable alternative to second-line medical treatment.
Aim: To assess short and long-term outcomes of patients operated on for inflammatory, ileocecal Crohn's disease.
Methods: A retrospective analysis of patients intervened at four referral hospitals during 2012-2021 was performed.
Aim: A laparoscopic approach to total colectomy (TC) for inflammatory bowel disease (IBD) is being increasingly used, but data on its comparative benefits over open TC are conflicting. The aim of this study was to examine 90-day outcomes following laparoscopic and open TC for IBD in a nationwide cohort after the introduction of laparoscopy.
Method: IBD patients undergoing TC in Denmark from 2005 to 2017 were identified from the Danish National Patient Registry.
Early surgical treatment for patients with ileocecal Crohn's disease (CD) could be an alternative to biological therapy. The aim of this study is to compare operative outcomes following ileocecal resection for patients with luminal and complicated CD. Patients operated for primary ileocecal CD during 8 years in one tertiary-referral hospital were allocated into 2 groups: those operated for early (luminal) disease (ECD), and for complications of CD (CCD).
View Article and Find Full Text PDFAim: Patients with inflammatory bowel disease (IBD) may undergo several abdominal surgeries with a risk of incisional hernia repair (IHR). The objectives of this study were to establish the risk of IHR and to analyse predictors of IHR after a first-time abdominal surgery for IBD.
Method: This Danish nationwide register-based cohort study (1996-2018) followed IBD patients from index operation until the date of IHR.
Background: Long-distance migratory birds undergo complex annual cycles during which they must adjust their behaviour according to the needs and conditions encountered throughout the year. Yet, variation in activity throughout the entire annual cycle has rarely been studied in wild migratory birds.
Methods: We used multisensor data loggers to evaluate the patterns of activity throughout the complete annual cycle of a long-distance migratory bird, the red-backed shrike Lanius collurio.
Background: Despite increasing focus on the technical performance of total mesorectal excision over recent decades, anastomotic leakage (AL) continues to be a serious complication for many patients, even in the hands of experienced surgical teams. This study describes implementation of standardized surgical technique in an effort to reduce variability, decrease the risk of anastomotic leakage, and improve associated short-term outcomes for rectal cancer patients undergoing robot-assisted restorative rectal resection (RRR).
Methods: We evaluated all rectal cancer patients undergoing robot-assisted RRR at Aarhus University Hospital between 2017 and 2020.
Strictures and abdominal pain often complicate Crohn's disease (CD). The primary aim was to explore whether parameters obtained by preoperative contrast-enhanced (CE) ultrasonography (US) and dynamic CE MR Enterography (DCE-MRE) of strictures associates with biomechanical properties. CD patients undergoing elective small intestinal surgery were preoperatively examined with DCE-MRE and CEUS.
View Article and Find Full Text PDFPurpose: To investigate functional outcomes and quality of life (QoL) after restorative proctocolectomy (RPC) using transanal minimal invasive surgery (TAMIS).
Method: The study consists of two sub-studies. A cohort study comprised 98 consecutive patients, who underwent TAMIS RPC.
Phenology has emerged as a key metric to measure how species respond to changes in climate. Innovative means have been developed to extend the temporal and spatial range of phenological data by obtaining data from herbarium specimens, citizen science programs, and biodiversity data repositories. These different data types have seldom been compared for their effectiveness in detecting environmental impacts on phenology.
View Article and Find Full Text PDFObjectives: We aimed to produce clinical recommendations for colonoscopic surveillance for dysplasia and colorectal cancer in patients with inflammatory bowel diseases.
Materials And Methods: The Danish Society for Gastroenterology and Hepatology convened a committee to assess the literature on colorectal cancer in inflammatory bowel diseases and the effectiveness of colonoscopy surveillance, according to the Oxford Centre for Evidence Based Medicine levels of evidence.
Results: Clinical recommendations for the colonoscopic surveillance for dysplasia and colorectal cancer in patients with inflammatory bowel diseases were produced.
Proc Natl Acad Sci U S A
December 2021
Migration allows animals to exploit spatially separated and seasonally available resources at a continental to global scale. However, responding to global climatic changes might prove challenging, especially for long-distance intercontinental migrants. During glacial periods, when conditions became too harsh for breeding in the north, avian migrants have been hypothesized to retract their distribution to reside within small refugial areas.
View Article and Find Full Text PDFBackground: The impact of a stoma on long-term health-related quality of life in people living with ileostomies is not clear.
Objective: This study aimed to describe important patient-reported outcomes and health-related quality of life in people with ileostomies.
Design: This is a population-based, cross-sectional study.
Monitoring insects across space and time is challenging, due to their vast taxonomic and functional diversity. This study demonstrates how nets mounted on rooftops of cars (car nets) and DNA metabarcoding can be applied to sample flying insect richness and diversity across large spatial scales within a limited time period. During June 2018, 365 car net samples were collected by 151 volunteers during two daily time intervals on 218 routes in Denmark.
View Article and Find Full Text PDFUnderstanding the spatiotemporal patterns of legacy organochlorines (OCs) is often difficult because monitoring practices differ among studies, fragmented study periods, and unaccounted confounding by ecological variables. We therefore reconstructed long-term (1939-2015) and large-scale (West Greenland, Norway, and central Sweden) trends of major legacy OCs using white-tailed eagle (Haliaeetus albicilla) body feathers, to understand the exposure dynamics in regions with different contamination sources and concentrations, as well as the effectiveness of legislations. We included dietary proxies (δC and δN) in temporal trend models to control for potential dietary plasticity.
View Article and Find Full Text PDFEach year, billions of songbirds cross large ecological barriers during their migration. Understanding how they perform this incredible task is crucial to predict how global change may threaten the safety of such journeys. Earlier studies based on radar suggested that most songbirds cross deserts in intermittent flights at high altitude, stopping in the desert during the day, while recent tracking with light loggers suggested diurnal prolongation of nocturnal flights and common non-stop flights for some species.
View Article and Find Full Text PDFWe reconstructed the first long-term (1968-2015) spatiotemporal trends of perfluoroalkyl substances (PFAS) using archived body feathers of white-tailed eagles () from the West Greenland ( = 31), Norwegian ( = 66), and Central Swedish Baltic coasts ( = 50). We observed significant temporal trends of perfluorooctane sulfonamide (FOSA), perfluorooctane sulfonate (PFOS), and perfluoroalkyl carboxylates (∑PFCAs) in all three subpopulations. Concentrations of FOSA and PFOS had started decreasing significantly since the mid-1990s to 2000 in the Greenland and Norwegian subpopulations, consistent with the 3M phase-out, though in sharp contrast to overall increasing trends observed in the Swedish subpopulation.
View Article and Find Full Text PDFProtandry, the earlier arrival of males at the breeding grounds relative to females, is common in migratory birds. However, due to difficulties in following individual birds on migration, we still lack knowledge about the spatiotemporal origin of protandry during the annual cycle, impeding our understanding of the proximate drivers of this phenomenon. Here, we use full annual cycle tracking data of red-backed shrikes Lanius collurio to investigate the occurrence of sex-related differences in migratory pattern, which could be viewed as precursors (proximate causes) to protandry.
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