Publications by authors named "Anders R Malm"
Objective: To compare the effect of anti-reflux surgery (ARS) versus proton pump inhibitor therapy on lower oesophageal sphincter (LOS) function and oesophageal acid exposure in patients with chronic gastro-oesophageal reflux disease (GORD) over a decade of follow-up.
Material And Methods: In this randomised, prospective, multicentre study we compared LOS pressure profiles, as well as oesophageal exposure to acid, at baseline and at 1 and 10 years after randomisation to either open ARS (n = 137) or long-term treatment with omeprazole (OME) 20-60 mg daily (n = 108).
Results: Median LOS resting pressure and abdominal length increased significantly and remained elevated in patients operated on with ARS, as opposed to those on OME.
Article Synopsis
- AZD0837 is an experimental oral anticoagulant that converts to an active form, AR-H067637, which selectively inhibits thrombin to prevent blood clots.
- The study aimed to assess the potential adverse effects of intravenous AZD0837 on heart function and to evaluate its overall safety and tolerability in participants with atrial flutter.
- Results indicated that AZD0837 did not lead to significant changes in cardiac conduction, refractoriness, or repolarization, demonstrating it was well tolerated in the subjects.