Publications by authors named "Anders Holten Springborg"
Article Synopsis
- The study explores the link between pain catastrophizing (a psychological condition) and acute pain levels after unicompartmental knee arthroplasty (UKA), contrasting with prior research on total knee arthroplasty.
- Conducted as a prospective observational study, it involved 125 UKA patients, evaluating their postoperative pain through a diary at various intervals after surgery.
- Findings revealed that while 31% were predicted high-pain responders, preoperative pain catastrophizing did not correlate significantly with higher pain during the first week post-surgery.
The objective of this study was to develop a population pharmacokinetic-pharmacodynamic model of subcutaneously administered bupivacaine in a novel extended-release microparticle formulation for postoperative pain management. Bupivacaine was administered subcutaneously in the lower leg to 28 healthy male subjects in doses from 150 to 600 mg in a phase 1 randomized, placebo-controlled, double-blind, dose-ascending study with two different microparticle formulations, LIQ865A and LIQ865B. Warmth detection threshold was used as a surrogate pharmacodynamic endpoint.
View Article and Find Full Text PDFA novel microparticle-based extended-release local anaesthetic containing a bupivacaine/poly-lactic-co-glycolic acid (PLGA; LIQ865A) or plain bupivacaine (LIQ865B) was examined in a first-in-human trial. The objectives were to examine the dose safety/tolerability and pharmacodynamics. Randomized subcutaneous injections of LIQ865A (n = 16) or LIQ865B (n = 12) and diluent, contralaterally, were administered in a dose-ascending manner (150- to 600-mg bupivacaine).
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