Publications by authors named "Anders G Skjerbaek"

Unlabelled: This review investigated the psychometric properties of the most commonly used short-, long-, complex- and patient-reported walking outcome measures in multiple sclerosis(MS): the timed-25-foot walk test (T25FW), the six-minute walk test (6MWT), the six-spot step-test (SSST), and the 12-item MS walking scale (MSWS-12), along with reported reference data of these tests.

Methods: Based on PubMed and Embase searches, psychometric as well as descriptive data of T25FW, 6MWT, SSST, and MSWS-12 were extracted from studies evaluating persons with MS (pwMS). Descriptive data was also extracted from healthy controls (HC), if reported.

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Article Synopsis
  • Inpatient rehabilitation improves health-related quality of life (HRQOL) for multiple sclerosis (MS) patients, but the benefits often lessen after returning home, prompting a study on monthly telecoaching to sustain improvements.
  • A one-year study compared two telecoaching methods (telephone and web-based) to see if they could help maintain HRQOL post-discharge, using a neuropsychological group and a physical group for analysis.
  • Results showed that the neuropsychological group experienced long-term HRQOL benefits from telecoaching, particularly with one-on-one phone support, while the physical group did not see any significant improvement.
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  • The study explored the effectiveness of multidisciplinary rehabilitation (MDR) for individuals with multiple sclerosis (MS), highlighting the complexities of their symptoms and diverse treatment needs.
  • A randomized controlled trial was conducted with follow-up assessments focused on five main areas: Resilience, Cognitive Function, Energy, Physical Function, and Personal Needs, measuring outcomes using the Functional Assessment of Multiple Sclerosis (FAMS) tool.
  • Results showed significant improvements in FAMS scores at discharge for all focus areas, though the extent and durability of these improvements varied, underscoring the importance of tailored goal-setting in MDR for better health outcomes.
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Background: In Multiple Sclerosis, it has been demonstrated that balance is related to performances in walking tasks at different levels of complexity. However, it is unknown how the different sensory systems involved in balance control contribute to walking. This observational study investigates the associations between somatosensory, vestibular, and visual systems and measures of self-reported walking and walking capacity at different complexity levels (i.

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Article Synopsis
  • A study compared walking capacity in individuals with multiple sclerosis (MS) to healthy controls using three tests: the timed 25-foot walk test, the six-minute walk test, and the six-spot step test.
  • Researchers found significant walking impairments in MS patients across all tests, with deficits of 26%, 36%, and 44% for each respective test compared to healthy individuals.
  • The six-spot step test was identified as the most effective in detecting these walking capacity impairments among the tested options.
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Introduction: The Six Spot Step Test has shown good psychometric properties in terms of validity and reliability in people with multiple sclerosis. Yet, the responsiveness and minimal important change are unknown. The objective was to investigate the responsiveness of the Six Spot Step Test against the perceived change of walking limitations and establish estimates for the minimal important change in people with multiple sclerosis.

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Article Synopsis
  • The article focuses on how individuals with multiple sclerosis (MS) experience and manage feelings of control and uncertainty in their daily lives.
  • Through qualitative interviews with 23 people with MS and four of their relatives in Denmark, the study identifies three main themes related to the uncertainty of living with the disease: bodily control issues, symptom fluctuations, and the interpretation of these experiences.
  • The findings highlight that dealing with uncertainty is essential for those living with MS, urging healthcare professionals to incorporate an understanding of these uncertainties into rehabilitation and treatment discussions.
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Background And Purpose: In aging, lower extremity muscle power is undoubtedly one of the most important parameters of neuromuscular function implicating lower extremity physical function (e.g. walking capacity).

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  • A study investigated the impact of personalized inpatient multidisciplinary rehabilitation (MDR) on physical function in patients with multiple sclerosis (MS), focusing on clinically relevant improvements.
  • Over four weeks, patients underwent various tests to measure walking capacity and upper extremity function, showing significant improvements at discharge, particularly in walking-related measures.
  • Although gains in function were maintained at a six-month follow-up, they no longer met the clinically relevant thresholds, indicating that while MDR had beneficial effects, the long-term significance may vary by patient subgroup.
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Background: The lack of medical treatment options to reduce fatigue in patients with multiple sclerosis (MS) emphasize the importance of identifying potential non-pharmacological modifiable factors, as this may help advance current treatment strategies. The aim of this study was to identify potential modifiable lifestyle factors as well as patient- and disease-related characteristics, that are associated with fatigue in a large sample of clinically well-characterized patients with MS.

Methods: This study was a secondary analysis of a pragmatic randomized controlled trial of inpatient multidisciplinary rehabilitation in Denmark.

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Background: Inpatient multidisciplinary rehabilitation (MDR) can improve health-related quality of life (HRQoL) in multiple sclerosis (MS) patients. However, the evidence of a long-term benefit is limited.

Objectives: To investigate the long-term effectiveness of inpatient MDR on HRQoL in MS patients.

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Background: In multiple sclerosis (MS), the Expanded Disability Status Scale (EDSS) reflects disease severity. Although parts of the EDSS are dependent on actual walking distance, self-reported statements are often applied.

Objectives: The purpose of the present study was, therefore, to compare self-reported walking distance to actual walking distance to outline how this influences EDSS scoring.

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Background: The Six Spot Step Test (SSST) extends traditional walking outcomes in persons with multiple sclerosis (PwMS) by further challenging components of coordination and balance. Nonetheless, the test-retest agreement of the SSST has not been investigated.

Objective: To determine the within-day, day-to-day, and inter-rater agreement and reliability of the SSST in PwMS.

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Background: Heat sensitivity (HS) is reported by 58% of all persons with multiple sclerosis (MS), causing symptom exacerbation possibly limiting exercise participation.

Objective: The purpose of this study was to test the hypotheses that (a) a relationship between exercise-induced changes in core-temperature (C(temp)) and changes in symptom intensity exists, and (b) that resistance exercise (RE), as a consequence of a minor increase in core temperature, will induce a lesser worsening of symptoms than endurance exercise (EE) in HS persons with MS.

Methods: On two separate days, 16 HS persons with MS randomly completed a session of RE and EE, or EE and RE, respectively.

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Purpose: To investigate; (i) the relationship between the 5STS-test and lower extremity muscle strength and balance, and (ii) the variability of the 5STS-test in multiple sclerosis (MS) patients.

Method: 22 MS patients were divided into two groups (Group A and Group B) who completed one 5STS familiarization test session and two testing sessions. In Group A, session 1 also included assessment of lower extremity muscle strength.

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