Practical kidney dosimetry in peptide receptor radionuclide therapy using [Lu]Lu-DOTATOC and [Lu]Lu-DOTATATE with focus on uncertainty estimates.

Background: Kidney dosimetry after peptide receptor radionuclide therapy using Lu-labelled somatostatin analogues is a procedure with multiple steps. We present the SPECT/CT-based implementation at Aarhus University Hospital and evaluate the uncertainty of the various steps in order to estimate the total uncertainty and to identify the major sources of uncertainty. Absorbed dose data from 115 treatment fractions are reported.

Neodymium-140 DOTA-LM3: Evaluation of an Generator for PET with a Non-Internalizing Vector.

Nd ( = 3.4 days), owing to its short-lived positron emitting daughter Pr ( = 3.4 min), has promise as an generator for positron emission tomography (PET).

Mouse Positron Emission Tomography Study of the Biodistribution of Gold Nanoparticles with Different Surface Coatings Using Embedded Copper-64.

By taking advantage of the ability of Cu to bind nonspecifically to gold surfaces, we have developed a methodology to embed this radionuclide inside gold nanoparticles (AuNPs). Cu enables the in vivo imaging of AuNPs by positron emission tomography (PET). AuNPs have a multitude of uses within health technology and are useful tools for general nanoparticle research.