Publications by authors named "Anders Boutrup Funch"
Article Synopsis
- Rubber accelerators like TETD and ZDEC, used in rubber vulcanization, can cause allergic reactions and may trigger cross-reactivity between each other.
- A study on mice showed that sensitization and subsequent exposure to either TETD or ZDEC resulted in increased skin irritation and immune cell proliferation.
- The findings indicate that individuals allergic to one compound may react to the other, suggesting such patients should avoid both substances to prevent allergic responses.
Background: CD8 epidermal-resident memory T (T ) cells play central roles in local flare-up responses to experimental contact allergens by inducing massive influx of neutrophils to the epidermis upon allergen challenge. Whether similar immunopathogenic mechanisms are involved in the responses to clinically relevant contact allergens is unknown.
Methods: The immune response to cinnamal, ρ-phenylenediamine (PPD) and methylisothiazolinone (MI) was studied in a well-established mouse model for allergic contact dermatitis that includes formation of T cells by ELISA, flow cytometry, fluorescence microscopy analyses and cell depletion protocols.