Population pharmacokinetics of 25-hydroxy vitamin D in children with asthma .

Objectives: Asthma and vitamin D deficiency are widespread in the pediatric and adolescent population. The aim of this study was to develop a population pharmacokinetic (PPK) model and to evaluate the most important factors that can significantly affect clearance of 25-hydroxy vitamin D in asthmatic children using PPK analysis.

Materials And Methods: The study population included school children and adolescents from 7 to 18 years of age of both sexes.

Diaphragmatic defect or pulmonary sequestration in a five-year-old boy.

This case report presents a 5-year-old boy with diaphragmatic defect with a tardy clinical manifestation. The findings of chest x-ray and chest CT scan were seen by pediatricians and radiologists as interstitial pneumonia and suspected pulmonary sequestration, pediatric surgeons saw it as a benign teratoma and during surgery a muscular defect of hemidiaphragm right was found. This case emphasize the rarity of diaphragmatic hernia in children of older age, the importance of "accented" clinical suspicion based on the maintenance of signs of mild respiratory failure, the need for additional radiological tests and surgery with the aim to diagnose this abnormality and "successfulness" of prenatal ultrasound examination.