Naturally occurring isohexenylnaphthazarins and wound healing: experimental study in dogs.

Background: The healing efficacy of isohexenylnaphthazarins (IHN) has been well proved on chronic or contaminated wounds.

Objective: To evaluate the wound healing activity of an experimental ointment containing IHN on acute and noncontaminated wounds in dogs.

Methods: In each of six beagle dogs, four full-thickness skin defects were created bilaterally: one 2 x 2 cm defect on the lateral aspect of each arm for subjective evaluation, laser Doppler flowmetry (LDF), and planimetry and three 1.