Publications by authors named "Anda Voulgari-Kokota"
Mesenchymal stem cells (MSC) provide therapeutic effects in experimental CNS disease models and show promise as cell-based therapies for humans, but their modes of action are not well understood. We previously show that MSC protect rodent neurons against glutamate excitotoxicity in vitro, and in vivo in an epilepsy model. Neuroprotection is associated with reduced NMDA glutamate receptor (NMDAR) subunit expression and neuronal glutamate-induced calcium (Ca) responses, and increased expression of stem cell-associated genes.
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- Understanding the molecular mechanisms of neuron death after a stroke is crucial for developing effective treatments.
- This study focused on death receptor signaling pathways' role in neuronal death after ischemia using various models, identifying key proteins involved in the process.
- The findings highlight the importance of TNFRI in activating neuroprotective pathways, revealing that manipulating these pathways could lead to new therapeutic strategies for stroke recovery.