Publications by authors named "Anda Cornelia Vizitiu"
Article Synopsis
- The study explores the molecular mechanisms behind Down syndrome, focusing on the expression levels of specific microRNAs (miR-99a) located on chromosome 21 in amniotic fluid from pregnancies with Down syndrome.
- It utilizes qRT-PCR methods to compare microRNA levels in samples from Down syndrome and typical pregnancies, identifying a notable up-regulation of mature miR-99a in female fetuses with Down syndrome.
- The findings suggest that the alteration in miR-99a expression may affect critical signaling pathways linked to heart development, potentially contributing to cardiac defects observed in female patients with Down syndrome.
The tremendous research effort of the last decades added a new, epigenetic layer of complexity to the already complex image of prostate cancer pathogenesis. Here we use quantitative real-time polymerase chain reaction (qRT-PCR) to investigate the expression of the microRNAs resident on chromosome 21 (miR-ch21) in laser capture microdissected (LCM) tissues from formalin-fixed paraffin-embedded (FFPE) archived, prostate adenocarcinoma samples. We show a strong, specific down-regulation of miR-ch21 in tumoral epithelia and stromae as compared to normal counterparts, results at odd with the current paradigm on the involvement of these microRNAs in prostate oncogenesis.
View Article and Find Full Text PDF