Publications by authors named "Ancong Xu"
Article Synopsis
- * Hyperbaric oxygen (HBO) therapy has shown promise in protecting against CNS injuries related to heatstroke, with studies indicating it improves survival rates and reduces neurological issues in heatstroke-affected rats while also lessening inflammatory responses.
- * HBO therapy works by preventing microglial pyroptosis, a form of cell death that contributes to neuroinflammation in the hippocampus, thereby alleviating heatstroke-induced damage in both rats and a mouse microglial cell line.
Article Synopsis
- The study investigated how heat stress (HS) affects the expression of interleukin-1β (IL-1β) and IL-18 in BV-2 microglial cells, focusing on the role of glutamate transmission.
- BV-2 cells were exposed to heat stress at 40°C and evaluated for glutamate release and the expression of related receptors and proteins, with some cells treated with glutamate or antagonists to study their effects.
- Results showed that HS increased glutamate levels and proinflammatory factors IL-1β and IL-18, but preincubation with specific drugs reduced these effects, suggesting microglia play a role in glutamate metabolism during heat stress.
Heat stroke alters hippocampal and cerebellar transmitter metabonomics.
World J Emerg Med
January 2023
Background: The mechanisms underlying heat stroke (HS)-induced hippocampal injury remain unclear. This study aimed to evaluate the HS-induced metabonomics of hippocampal and cerebellar transmitters.
Methods: The HS model was established with male Sprague-Dawley rats subjected to heat exposure of up to 42 °C at a humidity of (55.
Background: Acinetobacter baumannii is a gram-negative aerobic bacillus that is commonly causes of hospital-acquired infections. Community-acquired pneumonia caused by Acinetobacter baumannii (CAP-Ab) is rare but fatal if diagnosis and treatment are delayed. Conventional culture of clinical specimens is the main method for clinical diagnosis of A.
View Article and Find Full Text PDFRestenosis is liable to occur following treatment with endovascular interventional therapy. Increasing evidence indicates that hydrogen sulfide (H2S) exhibits numerous physiological properties, including antioxidative and cardioprotective disease properties. Thus, the present study aimed to investigate the anti‑restenosis effects of H2S and its protective mechanisms.
View Article and Find Full Text PDFThe pathology of proliferative vitreoretinopathy and proliferative diabetic retinopathy is linked to proliferation, migration, and adhesion of the retinal pigment epithelium. MicroRNA-34a (miR-34a) expression modulates changes in proliferation and migration of retinal pigment epithelial cell line ARPE-19. In this study, we determined that miR-34a interacts with LGR4, identified by bioinformatics using TargetScan Human 5.
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