A comparative analysis of phyto-components on EGFR binding, viability, and migration in HPV positive ME180 and HPV negative C33A cervical cancer cells.

A need for effective implementation of cervical cancer (CC) even in developed countries insist the urge for developing an effective drug molecule to treat CC. Previously, we showed an inverse correlation between survival of CC patients and epidermal growth factor (EGF) receptor (EGFR) levels. Newer tyrosine kinase inhibitors to treat CC are being constantly pursued.

Employing bioactive compounds derived from (L.) to evaluate potential inhibitor for SARS-CoV-2 main protease and ACE2 protein.

Angiotensin converting enzyme 2 (ACE2) and main protease (M) are significant target proteins, mainly involved in the attachment of viral genome to host cells and aid in replication of severe acute respiratory syndrome-coronaviruses or SARS-CoV genome. In the present study, we identified 11 potent bioactive compounds from ethanolic leaf extract of (L.) by using GC-MS analysis.

Structure-based virtual screening, pharmacokinetic prediction, molecular dynamics studies for the identification of novel EGFR inhibitors in breast cancer.

Breast cancer is one of the most prevalent malignancy cancer types especially affecting women globally. EGFR is a proto onco gene as well as the first identified tyrosine kinase receptor. It plays a dynamic role in many biological tasks such as apoptosis, cell cycle progression, differentiation, development and transcription.

Axial Plane Deformity of the Shoulder in Adolescent Idiopathic Scoliosis.

Study Design: Prospective observational study.

Objective: To study axial plane deformation of the shoulder in adolescent idiopathic scoliosis (AIS) and try to correlate it with curve type and surgical correction.

Summary Of Background Data: It is established that AIS is a 3-dimensional deformity.

Post-operative shoulder imbalance in adolescent idiopathic scoliosis: a study of clinical photographs.

Study Design: Retrospective observational study.

Objective: To assess what features determine post-operative shoulder asymmetry in Adolescent Idiopathic Scoliosis (AIS).

Summary Of Background Data: Shoulder balance is one of the major determinants of the cosmetic outcomes of AIS surgery.

Patterns of shoulder imbalance in adolescent idiopathic scoliosis: a retrospective observational study.

Study Design: Retrospective cohort study.

Objective: To study the relationship between the proximal spine and shoulder levels in adolescent idiopathic scoliosis (AIS).

Summary Of Background Data: It has been frequently observed that the shoulder levels do not correspond to the spinal curve direction in AIS.

Spontaneous spinal epidural haematoma: report of two cases and review of the literature.

The clinical presentation, investigation, management and outcome of two patients with spontaneous spinal epidural haematoma (SSEH) are presented. CT myelogram revealed an extradural compressive lesion in one patient and MRI confirmed extradural haemorrhage in the second. Both the cases were treated surgically.

Oral facial digital syndrome.

We report a female infant with features suggestive of Oral Facial Digital Syndrome (OFDS) Type I and associated cerebellar anomalies with Dandy-Walker malformation which suggest OFDS Type VI. The phenotypic overlap in this child OFDS type I and TypeVI raises the question as to whether they represent separate genetic entities. This pattern of abnormalities appears to be unique.